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Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a common childhood cancer that shares features with develo** skeletal muscle. Yet, the conservation of cellular hierarchy...
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Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration
Retinal degeneration (RD) is a leading cause of blindness worldwide and includes conditions such as retinitis pigmentosa (RP), age-related macular...
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Non-stem Cell Mediated Tissue Regeneration and Repair
Regrowth and replacement are two basic responses of the body to any injury. While regrowth is generally attributed to stem cells, and replacement or...
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Enhancing health span: muscle stem cells and hormesis
Sarcopenia is a significant public health and medical concern confronting the elderly. Considerable research is being directed to identify ways in...
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Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length
Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity. Spaceflight elongates human telomeres in peripheral blood,...
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3D human induced pluripotent stem cell–derived bioengineered skeletal muscles for tissue, disease and therapy modeling
Skeletal muscle is a complex tissue composed of multinucleated myofibers responsible for force generation that are supported by multiple cell types....
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Analysis of the C. elegans Germline Stem Cell Pool
The Caenorhabditis elegans germline is an excellent model for studying the genetic and molecular regulation of stem cell self-renewal and progression...
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Epitranscriptome Map** of N6-Methyladenosine Using m6A Immunoprecipitation with High Throughput Sequencing in Skeletal Muscle Stem Cells
N6-Methyladenosine (m6A), one of the most abundant chemical modifications in mRNA (epitranscriptome), contributes to the regulation of biological...
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Measuring Oxygen Consumption Rate (OCR) and Extracellular Acidification Rate (ECAR) in Muscle Stem Cells Using a Seahorse Analyzer: Applicability for Aging Studies
In recent years, evidence showing metabolism as a fundamental regulator of stem cell functions has emerged. In skeletal muscle, its stem cells...
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The Notch signaling network in muscle stem cells during development, homeostasis, and disease
Skeletal muscle stem cells have a central role in muscle growth and regeneration. They reside as quiescent cells in resting muscle and in response to...
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Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregulation and sensation. Hair...
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Cell death as an architect of adult skin stem cell niches
Our skin provides a physical and immunological barrier against dehydration and environmental insults ranging from microbial attacks, toxins and UV...
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Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice
With the expansion of the aging population, age-associated sarcopenia (AAS) has become a severe clinical disease of the elderly and a key challenge...
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Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are...
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DMRTA2 supports glioma stem-cell mediated neovascularization in glioblastoma
Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Due to its fast proliferation, diffusive growth and therapy resistance...
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Single-cell sequencing advances in research on mesenchymal stem/stromal cells
Mesenchymal stem/stromal cells (MSCs), originating from the mesoderm, represent a multifunctional stem cell population capable of differentiating...
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Avant-Garde Hydrogels as Stem Cell Niche for Cardiovascular Regenerative Medicine
Cardiovascular diseases remain the primary cause of death in the modern world. According to the World Health Organization (WHO), almost 18 million...
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Exploring distinct properties of endometrial stem cells through advanced single-cell analysis platforms
The endometrium is a dynamic tissue that undergoes cyclic changes in response to ovarian hormones during the menstrual cycle. These changes are...
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Promoting Alzheimer’s disease research and therapy with stem cell technology
BackgroundAlzheimer’s disease (AD) is a prevalent form of dementia leading to memory loss, reduced cognitive and linguistic abilities, and decreased...
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The role and therapeutic potential of stem cells in skeletal muscle in sarcopenia
Sarcopenia is a common age-related skeletal muscle disorder featuring the loss of muscle mass and function. In regard to tissue repair in the human...
