Search
Search Results
-
Characterization of two distinct immortalized endothelial cell lines, EA.hy926 and HMEC-1, for in vitro studies: exploring the impact of calcium electroporation, Ca2+ signaling and transcriptomic profiles
BackgroundDisruption of Ca 2+ homeostasis after calcium electroporation (CaEP) in tumors has been shown to elicit an enhanced antitumor effect with...
-
Cytosolic peptides encoding CaV1 C-termini downregulate the calcium channel activity-neuritogenesis coupling
L-type Ca 2+ (Ca V 1) channels transduce channel activities into nuclear signals critical to neuritogenesis. Also, standalone peptides encoded by Ca V 1...
-
Local production of reactive oxygen species drives vincristine-induced axon degeneration
Neurological side effects arising from chemotherapy, such as severe pain and cognitive impairment, are a major concern for cancer patients. These...
-
Alterations of the skeletal muscle contractile apparatus in necrosis induced by myotoxic snake venom phospholipases A2: a mini-review
Skeletal muscle necrosis is a common clinical manifestation of snakebite envenoming. The predominant myotoxic components in snake venoms are...
-
Root osmotic sensing from local perception to systemic responses
Plants face a constantly changing environment, requiring fine tuning of their growth and development. Plants have therefore developed numerous...
-
Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells
Differences in shape can be a distinguishing feature between different cell types, but the shape of a cell can also be dynamic. Changes in cell shape...
-
A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century
This chapter of the book is directed to PhD students, post-docs and young researchers who are attracted by the unique properties of voltage-gated...
-
Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways
Phenotypic and functional changes in vascular smooth muscle cells (VSMCs) contribute significantly to cardiovascular diseases (CVD) but factors...
-
Calcium and TRPV4 promote metastasis by regulating cytoskeleton through the RhoA/ROCK1 pathway in endometrial cancer
Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that has been associated with several types of cancer....
-
Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages
The danger signal extracellular calcium is pathophysiologically increased in the synovial fluid of patients with rheumatoid arthritis (RA). Calcium...
-
Protective Effect of Calcium Fructoborate Against Carbon Tetrachloride–Induced Toxicity in Rats
Carbon tetrachloride (CCl 4 ) is a xenbiotic that can cause cellular damage with free radical production. Calcium fructoborate (CFB) is a boron-based...
-
A stochastic mathematical model for coupling the cytosolic and sarcoplasmic calcium movements in diseased cardiac myocytes
Several computational studies have been undertaken to explore the Ca 2+ -induced Ca 2+ release (CICR) events in cardiac myocytes and along with...
-
Dispersal, habitat filtering, and eco-evolutionary dynamics as drivers of local and global wetland viral biogeography
Wetlands store 20–30% of the world’s soil carbon, and identifying the microbial controls on these carbon reserves is essential to predicting...
-
Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis
N-methyl-D-aspartate receptors (NMDAR) are glutamate-gated calcium channels named after their artificial agonist. NMDAR are implicated in cell...
-
Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response
Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary...
-
Unraveled roles of Cav1.2 in proliferation and stemness of ameloblastoma
BackgroundTranscriptome analysis has been known as a functional tool for cancer research recently. Mounting evidence indicated that calcium signaling...
-
Characteristics of the Adaptations of Epilithic Mosses to High-Calcium Habitats in the Karst Region of Southwest China
A high calcium level is an important ecological factor in karst regions. Studying the adaptation mechanism of karst plants to high-calcium...
-
Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone
BackgroundMechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43...
-
Calmodulin Regulation of Voltage-Gated Calcium Channels
The ubiquitous Ca2+ sensor calmodulin (CaM) serves as a preeminent modulator of voltage-gated Ca2+ channels, exerting rapid and powerful feedback...
-
Effects of calcium ion on the colony formation, growth, and photosynthesis in the edible cyanobacterium Nostoc sphaeroides
Calcium ions are crucial for the growth and development of photosynthetic organisms, whereas its eco-physiological significance on the edible...
