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Allosteric Sites and Allosteric Regulators of G Protein-Coupled Receptors: Gray Cardinals of Signal Transduction
AbstractMembrane G protein-coupled receptors (GPCRs) are key components of most eukaryotic signaling systems, transducing external signals to...
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Cannabis and Cancer
The International Agency for Research on Cancer report on the global burden of cancer estimated 18.1 million new cancer cases (17.0 million excluding...
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Cannabis-Induced Neuroactivity: Research Trends and Commercial Prospects
The worldwide interest and push for the legalization of cannabis/marijuana, especially in the United States, are increasing with each passing day....
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The Analgesic Effects of Cannabis
Drugs derived from Cannabis were used until the 1940s for their stimulant and depressant effects in treating somatic and psychiatric illnesses....
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Cannabigerol: a bibliometric overview and review of research on an important phytocannabinoid
Cannabigerol (CBG) is one of the major phytocannabinoids present in Cannabis sativa L. but is presumed to be an artefact or degradation product of...
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Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice
The mechanism underlying the transition from the pre-symptomatic to the symptomatic state is a crucial aspect of epileptogenesis. SYN2 is a member of...
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Cannabis and Parkinson’s Disease
Parkinson’s disease is a slowly progressive, degenerative disorder characterized by resting tremors, stiffness (rigidity), slow and decreased...
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Cannabis and Multiple Sclerosis
Multiple sclerosis (MS) is a chronic demyelinating disease of the central and peripheral nervous systems. The symptoms, such as vision problems,...
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Cannabis and Perinatal Development
Evidence supports the endocannabinoid (eCB) system’s role in the central nervous system patterning in structures relevant to mood, cognition, and...
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Promoting Oligodendrocyte Differentiation from Human Induced Pluripotent Stem Cells by Activating Endocannabinoid Signaling for Treating Spinal Cord Injury
Transplantation of oligodendrocyte progenitor cell (OPC) at the injury site is being developed as a potential therapeutic strategy for promoting...
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Machine Learning and Computational Chemistry for the Endocannabinoid System
Computational methods in medicinal chemistry facilitate drug discovery and design. In particular, machine learning methodologies have recently gained...
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Back to the plant: overcoming roadblocks to the microbial production of pharmaceutically important plant natural products
Microbial fermentation platforms offer a cost-effective and sustainable alternative to plant cultivation and chemical synthesis for the production of...
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Hypothalamic endocannabinoids in obesity: an old story with new challenges
The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and cellular mechanisms...
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The Bioactive Components of Cannabis
Cannabinoids (CBDs) represent a group of C21 or C22 terpenophenolic compounds predominantly produced by Cannabis but have also been found in plants...
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Comprehensive analysis of 19 cannabinoids in commercial CBD oils: concentrations, profiles, and safety implications
Nineteen cannabinoids, including Δ 9 -THC (tetrahydrocannabinol) and CBD (cannabidiol), were quantified in 22 CBD oils, 2 CBG (cannabigerol) oils, and...
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Cannabinoid exposure during pregnancy and its impact on immune function
Cannabinoids are the most commonly abused illicit drugs worldwide. While cannabis can be beneficial for certain heath conditions, abuse of potent...
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Neurological Effects of Cannabis
Cannabis products and Cannabis use are inherently variable. Given the difficulty in standardizing Cannabis products and Cannabis use patterns,...
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Microbial Production of Terpenes
Sustainability is one of the main challenges facing humankind in the twenty-first century due to the continuous increase in the demand for energy and...