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Mesenchymal Stem Cells for Bone and Cartilage Regeneration: State of the Art
Mesenchymal stem cells (MSCs) have essential applications in bone and cartilage regenerative medicine. Undifferentiated MSCs show a high...
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Breaking Barriers: Nucleic Acid Aptamers in Gastrointestinal (GI) Cancers Therapy
Conventional cancer therapies can have significant adverse effects as they are not targeted to cancer cells and may damage healthy cells....
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The Gene-Edited Babies Controversy: Reactions in the Scientific Community, Social Media, and the Press
This chapter analyzes how the gene-edited babies controversy sparked by He Jiankiu has unfolded in three spheres: the scientific community, the...
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Inhibition and reversal of a TGF-β1 induced myofibroblast phenotype by adipose tissue-derived paracrine factors
BackgroundHypertrophic scarring results from myofibroblast differentiation and persistence during wound healing. Currently no effective treatment for...
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Skeletal infections: microbial pathogenesis, immunity and clinical management
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many organisms are linked to skeletal infections, Staphylococcus...
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A Review on Next-Generation Nano-Antimicrobials in Orthopedics: Prospects and Concerns
Recently an increase in occurrence of bone implant infections leading to implant failure and need for revision surgery has been observed. The major...
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Relationship between biofilm-forming microorganisms (BFM: Staphylococcus aureus and Pseudomonas aeruginosa) and DEFB1 gene variants on β-defensin levels in periprosthetic joint infection (PJI)
BackgroundThe purpose of this study was to investigate the relationship between biofilm-forming microorganisms (BFM) and DEFB1 gene variants on...
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TNF-α-Inhibition Improves the Biocompatibility of Porous Polyethylene Implants In Vivo
Background:To improve the biocompatibility of porous polyethylene (PPE) implants and expand their application range for reconstructive surgery in...
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Breast Cancer Stem Cells: A Clinician’s View
Much has been revealed about breast cancer stem cells, their properties, and behavior and yet, a gap remains between the ever expanding knowledge and...
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Immunophenotype of Mesenchymal Stem Cells Derived from Epicardial and Perivascular Adipose Tissue in Patients with Cardiovascular Diseases
AbstractThe work was aimed to evaluate the immunophenotype of adipose tissue stem cells isolated from epicardial and perivascular fat depots in...
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Establishment and validation of early prediction model for hypertriglyceridemic severe acute pancreatitis
BackgroundThe prevalence of hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) is increasing due to improvements in living standards and...
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An Update Overview on Mechanistic Data and Biomarker Levels in Cobalt and Chromium-Induced Neurodegenerative Diseases
There is increasing evidence that the imbalance of metals as cobalt (Co) and chromium (Cr) may increase the risk of development and progression of...
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Potential Risks, Recommendations and Contraindication for WB-EMS Application
Due to the absence of high intensity, voluntary exercise, WB-EMS in general displays a lower orthopedic risk compared to similarly effective high...
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Mesenchymal Stem Cells for Bone and Cartilage Regeneration: State of the Art
Mesenchymal stem cells (MSCs) have essential applications in bone and cartilage regenerative medicine. Undifferentiated MSCs show a high...
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Myogenic Cardiac Regeneration: Clinical Studies Using Skeletal Myoblasts
Stem cell therapyStem cell therapy offers promising results for repopulating and regenerating damaged myocardium. In this regard, skeletal myoblasts...
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Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis
Orthogeriatrics is increasingly recommended in the care of hip fracture patients, although evidence for this model is conflicting or at least...
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Sources, Characteristics, and Therapeutic Applications of Mesenchymal Cells in Tissue Engineering
Tissue engineering (TE) is a therapeutic option within regenerative medicine that allows to mimic the original cell environment and functional...
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Candida Infectious Endocarditis and Implantable Cardiac Device Infections
Intravascular diseases due to Candida species, including endocarditis and cardiac device-associated infections, are rare yet devastating...
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Answering Criticisms of RCTs
In recent years, there have been several papers published, mainly by philosophers, criticising randomised controlled trials (RCTs). These include...