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Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells
BackgroundDiabetes is a disease affecting over 500 million people globally due to insulin insufficiency or insensitivity. For individuals with type 1...
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Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
SVA (SINE (short interspersed nuclear element)–VNTR (variable number of tandem repeats)– Alu ) retrotransposons remain active in humans and contribute...
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Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a malignant cancer and chemotherapy ineffectively treats PDAC, leading to the requirement for...
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Hyaluronan supports the limbal stem cell phenotype during ex vivo culture
BackgroundHyaluronan (HA) has previously been identified as an integral component of the limbal stem cell niche in vivo. In this study, we...
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Serum-Free Production of Three-Dimensional Hepatospheres from Pluripotent Stem Cells
Develo** renewable human liver tissue from stem cells has been pursued as a potential source of biological material for pharmaceutical and clinical...
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Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model
BackgroundHuman pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell replacement therapy but often lack standardized cell...
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Depletion of aneuploid cells in human embryos and gastruloids
Chromosomal instability leading to aneuploidy is pervasive in early human embryos
1 –3 and is considered as a major cause of infertility and pregnancy...
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The application of a 4D-printed chitosan-based stem cell carrier for the repair of corneal alkali burns
BackgroundCorneal alkali burns can lead to ulceration, perforation, and even corneal blindness due to epithelial defects and extensive cell necrosis,...
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Maturity of Pluripotent Stem Cell-Derived Cardiomyocytes and Future Perspectives for Regenerative Medicine
Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have numerous potential for the source of cardiomyocytes to replace dead cells in heart...
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Differentiation of EpiLCs on Micropatterned Substrates Generated by Micro-Contact Printing
During the last decades, signaling pathways responsible for the initiation of gastrulation in mammalian embryos have been identified. However, the...
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Decellularized Extracellular Matrix for Stem Cell Culture
Many decellularized extracellular matrices have been developed and applied to various bioindustrial applications. Similar to these applications,...
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Amyloid-β mediates intestinal dysfunction and enteric neurons loss in Alzheimer's disease transgenic mouse
Alzheimer's disease (AD) is traditionally considered as a brain disorder featured by amyloid-β (Aβ) deposition. The current study on whether...
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A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells
Human pluripotent stem cells (hPSCs) are capable of extensive self-renewal yet remain highly sensitive to environmental perturbations in vitro,...
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Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice
BackgroundThe purpose of this study was to investigate allogenic immune responses following the transplantation of insulin-producing cells (IPCs)...
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Binding of Brucella protein, Bp26, to select extracellular matrix molecules
BackgroundBrucella is a facultative intracellular pathogen responsible for zoonotic disease brucellosis. Little is known about the molecular basis...
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Rapid generation of purified human RPE from pluripotent stem cells using 2D cultures and lipoprotein uptake-based sorting
BackgroundDespite increasing demand, current protocols for human pluripotent stem cell (hPSC)-derived retinal pigment epithelium (RPE) remain time,...
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Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells
BackgroundVentral midbrain (VM) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously...
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Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes
Primary adult cardiomyocyte (aCM) represent the mature form of myocytes found in the adult heart. However, culture of aCMs in particular is...
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Moderne Techniken in der angewandten Zellkultur
Die Entwicklung neuer Techniken ist nicht nur für die Trendforschung wichtig, sondern ebenfalls für langfristig angelegte und gesellschaftsrelevante...
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p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids
In this study, we take advantage of human induced pluripotent stem (iPS) cell-derived neural stem cells and brain organoids to study the role of p53...
