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Development of the excitation-contraction coupling machinery and its relation to myofibrillogenesis in human iPSC-derived skeletal myocytes
BackgroundHuman induced pluripotent stem cells-derived myogenic progenitors develop functional and ultrastructural features typical of skeletal...
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The pericyte connectome: spatial precision of neurovascular coupling is driven by selective connectivity maps of pericytes and endothelial cells and is disrupted in diabetes
Functional hyperemia, or the matching of blood flow with activity, directs oxygen and nutrients to regionally firing neurons. The mechanisms...
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Measuring Mitochondrial Calcium Fluxes in Cardiomyocytes upon Mechanical Stretch-Induced Hypertrophy
Calcium Ca2+ regulation is a key component of numerous cellular functions. In cardiomyocytes, Ca2+ regulates excitation-contraction coupling and...
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Recent Advances in In Vitro Generation of Mature Cardiomyocytes
Human adult cardiomyocytes are one of the most sought-after and on-demand appropriate model systems to understand cardiomyocyte development and...
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Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2-mutation associated with dilated cardiomyopathy and left ventricular non-compaction
Dilated cardiomyopathy (DCM) is a primary myocardial disease, leading to heart failure and excessive risk of sudden cardiac death with rather poorly...
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Computational Biomechanics of Ventricular Dyssynchrony and Resynchronization Therapy
Cardiac resynchronization therapy (CRT) is one of the few effective treatments for dyssynchronous heart failure (HF), where heart function is...
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The role of cardiac microenvironment in cardiovascular diseases: implications for therapy
Due to aging populations and changes in lifestyle, cardiovascular diseases including cardiomyopathy, hypertension, and atherosclerosis, are the...
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Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural...
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Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy
Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), a common muscle disease that manifests with muscle weakness, wasting, and...
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Arginine ingestion inhibits phagocyte invasion in eccentrically contracted rat fast-twitch muscle
Eccentric contraction (ECC) has been shown to induce leukocyte invasion into skeletal muscle, resulting in muscle inflammation. This study aimed to...
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Basic Structure of Skeletal Muscle
Building on the foundational understanding established in the first chapter, Chap. 2 explores the burgeoning...
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Skeletal muscle cells opto-stimulation by intramembrane molecular transducers
Optical stimulation and control of muscle cell contraction opens up a number of interesting applications in hybrid robotic and medicine. Here we show...
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Nitric oxide and ion channels mediate l-cysteine-induced inhibition of colonic smooth muscle contraction
Previous studies have suggested that l -cysteine regulates gut motility through hydrogen sulfide. However, the mechanisms involved in the l -cysteine-in...
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Effect of Eu3+ on Calcium-Dependent Processes in Vertebrate Myocardium
AbstractThe inotropic and chronotropic effects of Eu 3+ on spontaneous atrial contraction of the frog Rana ridibunda myocardium at different...
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Second Harmonic Generation Morphometry of Muscle Cytoarchitecture in Living Cells
The architectural structure of cells is essential for the cells’ function, which becomes especially apparent in the highly “structure functionally”...
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ATP Causes Contraction of Denervated Skeletal Muscles
AbstractThe ability of humoral agonists (and their persistent analogues) to induce contractions of denervated m. soleus and m. extensor digitorum...
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Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products
Cyclobutanes are distributed widely in a large class of natural products featuring diverse pharmaceutical activities and intricate structural...
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Human Myoblast Genome Therapy and the Regenerative Heart
Heart muscle degeneration leading to heart failure is one of the most debilitating and fatal conditions affecting mankind. Over the past 22 years,...
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Cardiac contractility of the African sharptooth catfish, Clarias gariepinus: role of extracellular Ca2+, sarcoplasmic reticulum, and β-adrenergic stimulation
This study investigated the dependence of contraction from extracellular Ca 2+ , the presence of a functional sarcoplasmic reticulum (SR), and the...
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