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Myeloid CCN3 protects against aortic valve calcification
BackgroundCellular communication network factor 3 (CCN3) has been implicated in the regulation of osteoblast differentiation. However, it is not...
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Whole-genome selection signature differences between Chaohu and Ji’an red ducks
Assessing the genetic structure of local varieties and understanding their genetic data are crucial for effective management and preservation....
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FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
BackgroundThe immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in...
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RETRACTED ARTICLE: BMP2 secretion from hepatocellular carcinoma cell HepG2 enhances angiogenesis and tumor growth in endothelial cells via activation of the MAPK/p38 signaling pathway
BackgroundHepatocellular carcinoma (HCC) is one of the most common tumors globally, with varying prevalence based on endemic risk factors. Bone...
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Zoledronate Promotes Peri-Implant Osteogenesis in Diabetic Osteoporosis by the AMPK Pathway
Together with diabetic osteoporosis (DOP), diabetes patients experience poor peri-implant osteogenesis following implantation for dentition defects....
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Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway
BackgroundTooth development, as one of the major mineralized tissues in the body, require fine-tuning of mineralization micro-environment. The...
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Features of Induction of In Vitro Osteodifferentiation of Adipose-Derived Mesenchymal Stem Cells
The features of osteogenic differentiation of mesenchymal stem cells (MSCs) of dogs, native and genetically modified, have been compared when...
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Inactivation of Ihh in Sp7-Expressing Cells Inhibits Osteoblast Proliferation, Differentiation, and Bone Formation, Resulting in a Dwarfism Phenotype with Severe Skeletal Dysplasia in Mice
Indian hedgehog (Ihh) is an indispensable paracrine factor for proper tissue patterning, skeletogenesis, and cellular proliferation. Recent genetic...
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Investigating skeletal deformities in Murray cod (Maccullochella peelii): a comprehensive study combining transcriptomics and histology
The Murray cod ( Maccullochella peelii ), an economically and recologically valuable fish species, is extensively cultured in the aquaculture industry....
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Long Non-coding RNA XIST May Influence Cervical Ossification of the Posterior Longitudinal Ligament Through Regulation of miR-17-5P/AHNAK/BMP2 Signaling Pathway
Long non-coding RNAs (lncRNAs) play an important role in the development of bone-related diseases. This study was conducted to investigate the role...
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Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration
BackgroundSignal peptide-CUB-EGF domain-containing protein 3 (SCUBE3), a secreted multifunctional glycoprotein whose transcript expression is...
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Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans
BackgroundBone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in...
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Identification of hub genes and pathways in colitis-associated colon cancer by integrated bioinformatic analysis
BackgroundColitis-associated colon cancer (CAC) patients have a younger age of onset, more multiple lesions and invasive tumors than sporadic colon...
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Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
BackgroundSomatic stem cell transplantation has been performed for cartilage injury, but the reparative mechanisms are still conflicting. The...
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Bone Morphogenetic Protein 2/4 in Mollusk, Haliotis diversicolor: Its Expression and Osteoinductive Function In Vitro
Bone morphogenetic proteins (BMPs), which are members of the superfamily of transforming growth factor-β (TGF-β), are known both in vitro and in vivo...
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Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses
The most frequent fetal birth defect associated with prenatal Zika virus (ZIKV) infection is brain calcification, which in turn may potentially...
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The role of miRNA and lncRNA in heterotopic ossification pathogenesis
Heterotopic ossification (HO) is the formation of bone in non-osseous tissues, such as skeletal muscles. The HO could have a genetic or a non-genetic...
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Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis
BackgroundAloe polysaccharide (AP) is a type of an active macromolecule of Aloe vera, which contributes to its function. However, whether AP...
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Unveiling the transcriptomic landscape and the potential antagonist feedback mechanisms of TGF-β superfamily signaling module in bone and osteoporosis
BackgroundTGF-β superfamily signaling is indispensable for bone homeostasis. However, the global expression profiles of all the genes that make up...
