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Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolism of surfactant material, a...
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Simple Models of Lung Development
Models are essential to further our understanding of lung development and regeneration and to facilitate identification and testing of potential...
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A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
Organoids have been an exciting advancement in stem cell research. Here we describe a strategy for directed differentiation of human pluripotent stem...
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Intranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation
Allergic airway inflammation (AAI), including allergic rhinitis (AR) and allergic asthma, is driven by epithelial barrier dysfunction and type 2...
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Mechanics of Lung Development
We summarize how skeletal muscle and lung developmental biology fields have been bridged to benefit from mouse genetic engineering technologies and...
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Upper respiratory tract microbiota is associated with small airway function and asthma severity
BackgroundCharacteristics of airway microbiota might influence asthma status or asthma phenotype. Identifying the airway microbiome can help to...
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The dynamic lung microbiome in health and disease
New methods and technologies within the field of lung biology are beginning to shed new light into the microbial world of the respiratory tract. Long...
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Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions
The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) remains largely unexplored. We present a landscape of...
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Engineering and Modeling the Lung Mesenchyme
The structure of the mammalian lung controls the flow of air through the airways and into the distal alveolar region where gas exchange occurs....
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Circulating SSEA-1+ stem cell-mediated tissue repair in allergic airway inflammation
Structural changes known as airway remodeling characterize chronic/severe asthma and contribute to lung dysfunction. We previously reported that...
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Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
BackgroundAsthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the...
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Engineering Dynamic 3D Models of Lung
The lung parenchyma—consisting of gas-filled alveoli, vasculature, and connective tissue—is the site for gas exchange in the lung and plays a...
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Lactobacillus rhamnosus Modulates Lung Inflammation and Mitigates Gut Dysbiosis in a Murine Model of Asthma-COPD Overlap Syndrome
The asthma-COPD overlap syndrome (ACOS) presents lung inflammation similar to both asthma and chronic obstructive pulmonary disease (COPD). Due to...
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Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis
Transient, tissue-specific, embryonic progenitors are important cell populations in vertebrate development. In the course of respiratory system...
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Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions
N-acetyltransferase 10 (NAT10), a nuclear acetyltransferase and a member of the GNAT family, plays critical roles in RNA stability and translation...
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Effects of condensates from volcanic fumaroles and cigarette smoke extracts on airway epithelial cells
The impact of volcanic airborne products on airway epithelium homeostasis is largely unknown. This study assessed the effects of volcanic Fumarole...
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A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
The lung contains numerous specialized cell types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms...
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Lung-on-a-Chip Models of the Lung Parenchyma
Since the publication of the first lung-on-a-chip in 2010, research has made tremendous progress in mimicking the cellular environment of healthy and...
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Loss of E-cadherin is causal to pathologic changes in chronic lung disease
Epithelial cells line the lung mucosal surface and are the first line of defense against toxic exposures to environmental insults, and their...
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A viral assembly inhibitor blocks SARS-CoV-2 replication in airway epithelial cells
The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the need for innovative therapies with high genetic barriers to...
