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The role of the ER stress sensor IRE1 in cardiovascular diseases
Despite enormous advances in the treatment of cardiovascular diseases, including I/R injury and heart failure, heart diseases remain a leading cause...
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The mechanisms of exercise improving cardiovascular function by stimulating Piezo1 and TRP ion channels: a systemic review
Mechanosensitive ion channels are widely distributed in the heart, lung, bladder and other tissues, and plays an important role in exercise-induced...
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Impact of prematurity on lifelong cardiovascular health: structural and functional considerations
The aetiology of preterm cardiovascular disease formation appears different from that of traditional population. Within the ‘traditional’ population...
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The therapeutic value of bifidobacteria in cardiovascular disease
There has been an increase in cardiovascular morbidity and mortality over the past few decades, making cardiovascular disease (CVD) the leading cause...
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Extracellular Microvesicles vs. Mitochondria: Competing for the Top Spot in Cardiovascular Regenerative Medicine
Regenerative medicine aims to restore, replace, and regenerate human cells, tissues, and organs. Despite significant advancements, many cell therapy...
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The role of lactate in cardiovascular diseases
Cardiovascular diseases pose a major threat worldwide. Common cardiovascular diseases include acute myocardial infarction (AMI), heart failure,...
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Cardiovascular and Immune Systems
Birds have high metabolic rates and so require an efficient cardiovascular system that provides their cells and tissues with sufficient oxygen. Birds...
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Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health
Obesity is a leading cause of morbidity and mortality globally. While the prevalence of obesity has been increasing, the incidence of its related...
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Influence of the Gut Microbiome on Cardiovascular Health and Hypertension
Cardiovascular diseases are characterized by high rates of morbidity and mortality. Microbiota are closely associated with cardiovascular disease....
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The pig as an optimal animal model for cardiovascular research
Cardiovascular disease is a worldwide health problem and a leading cause of morbidity and mortality. Preclinical cardiovascular research using...
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Gene editing and therapy in acquired and inherited cardiovascular disorders
Gene editing and therapy holds immense promise in addressing cardiovascular disorders by enabling precise modifications to the genetic groundworks of...
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The role of cardiac microenvironment in cardiovascular diseases: implications for therapy
Due to aging populations and changes in lifestyle, cardiovascular diseases including cardiomyopathy, hypertension, and atherosclerosis, are the...
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Ferroptosis in cardiovascular diseases: role and mechanism
In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years...
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Acute cardiovascular and muscular response to rowing ergometer exercise in artificial gravity – a pilot trial
Prolonged immobilization and spaceflight cause cardiovascular and musculoskeletal deconditioning. Combining artificial gravity through short-arm...
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Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk
High protein intake is common in western societies and is often promoted as part of a healthy lifestyle; however, amino-acid-mediated mammalian...
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Mitochondrial calcium uniporter channel gatekee** in cardiovascular disease
The mitochondrial calcium ( m Ca 2+ ) uniporter channel (mtCU) resides at the inner mitochondrial membrane and is required for Ca 2+ to enter the...
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Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
Until recently, the main pharmaceuticals used to control cholesterol and prevent cardiovascular disease (CVD) were statin-related drugs, known for...
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Cardiovascular correlates of epigenetic aging across the adult lifespan: a population-based study
Individuals with a similar chronological age can exhibit marked differences in cardiovascular risk profiles, but it is unknown whether this variation...
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Current and future strategies for targeting the endothelin pathway in cardiovascular disease
The first endothelin (ET)-1 receptor antagonist was approved for clinical use over 20 years ago, but to date this class of compounds has been limited...
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Role of lipins in cardiovascular diseases
Lipin family members in mammals include lipins 1, 2, and 3. Lipin family proteins play a crucial role in lipid metabolism due to their...
