Search
Search Results
-
Mitochondrial genomes of two parasitic Cuscuta species lack clear evidence of horizontal gene transfer and retain unusually fragmented ccmFC genes
BackgroundThe intimate association between parasitic plants and their hosts favours the exchange of genetic material, potentially leading to...
-
Alternative splicing modulates cancer aggressiveness: role in EMT/metastasis and chemoresistance
Enhanced metastasis and disease recurrence accounts for the high mortality rates associated with cancer. The process of Epithelial-Mesenchymal...
-
SMaRT for Therapeutic Purposes
Spliceosome-mediated mRNA trans-splicing (SMaRT) is a promising strategy for treatment of genetic diseases which cannot be targeted via classical...
-
SLFinder, a pipeline for the novel identification of splice-leader sequences: a good enough solution for a complex problem
BackgroundSpliced Leader trans-splicing is an important mechanism for the maturation of mRNAs in several lineages of eukaryotes, including several...
-
Confirmation of Transcriptional Read-Through Events by RT-PCR
Chimeric RNAs can be formed by trans-splicing from different transcripts or cis-splicing of adjacent genes (cis-SAGe). Cis-SAGe results from...
-
Comparative RNA-Seq analysis of the root revealed transcriptional regulation system for aluminum tolerance in contrasting indica rice of North East India
Expression pattern of aluminum (Al) tolerance genes is one of the major determinants of Al avoidance/tolerance within plant cultivars. We have...
-
Preliminary result of de novo transcriptome sequencing of the marine toxic dinoflagellate Alexandrium catenella incubated under several different stresses
In cold water coastal regions, the marine dinoflagellate Alexandrium catenella (Group I) is associated with paralytic shellfish poisoning. Here, we...
-
Comparing de novo transcriptome assembly tools in di- and autotetraploid non-model plant species
BackgroundPolyploidy is very common in plants and can be seen as one of the key drivers in the domestication of crops and the establishment of...
-
Single-cell genomics unveils a canonical origin of the diverse mitochondrial genomes of euglenozoans
BackgroundThe supergroup Euglenozoa unites heterotrophic flagellates from three major clades, kinetoplastids, diplonemids, and euglenids, each of...
-
The biosynthesis and functional roles of methylated nucleosides in eukaryotic mRNA
Modified nucleosides are present in mRNA of all eukaryotes, albeit at much lower levels than in other RNA moieties such as rRNA, tRNA, and snRNA....
-
Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm
Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants and has become a key nematode...
-
The unfolded protein response unfolds
As a key organelle of protein targeting and secretion, the endoplasmic reticulum (ER) plays host to a wide variety of protein maturation steps...
-
Detection of Group II Intron-Generated Chimeric mRNAs in Bacterial Cells
Chimeric RNAs are the transcripts composed of exons from two separate genes or transcripts. Although the presence of these joined RNA molecules have...
-
Identification of eQTLs and sQTLs associated with meat quality in beef
BackgroundTranscription has a substantial genetic control and genetic dissection of gene expression could help us understand the genetic architecture...
-
Variations of intronic branchpoint motif: identification and functional implications in splicing and disease
The branchpoint (BP) motif is an essential intronic element for spliceosomal pre-mRNA splicing. In mammals, its sequence composition, distance to the...
-
Conservative route to genome compaction in a miniature annelid
The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often...
-
Importance of pre-mRNA splicing and its study tools in plants
Alternative splicing (AS) significantly enriches the diversity of transcriptomes and proteomes, playing a pivotal role in the physiology and...
-
A novel adenylate isopentenyltransferase 5 regulates shoot branching via the ATTTA motif in Camellia sinensis
BackgroundShoot branching is one of the important agronomic traits affecting yields and quality of tea plant ( Camellia sinensis ). Cytokinins (CTKs)...
-
Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection
BackgroundChromosome-level assemblies are indispensable for accurate gene prediction, synteny assessment, and understanding higher-order genome...
-
Base-Editor-Mediated circRNA Knockout by Targeting Predominantly Back-Splice Sites
Back-splicing of eukaryotic exon(s) leads to the production of covalently closed circular RNAs (circRNAs). Generally, most circRNAs contain...