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Establishment of a set of wheat-rye addition lines with resistance to stem rust
Key messageComplete new wheat-rye disomic, telosomic addition lines and various chromosomal aberrations were developed and characterized by molecular...
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QTL associated with Gummy Stem Blight (GSB) resistance in watermelon
BackgroundGummy stem blight (GSB), caused by Didymella bryoniae (syn. Stagonosporopsis cucurbitacearum ), produces devastating symptoms on whole...
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CDKN2A promoter methylation enhances self-renewal of glioblastoma stem cells and confers resistance to carmustine
BackgroundGlioblastoma, a highly aggressive form of brain cancer, poses significant challenges due to its resistance to therapy and high recurrence...
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Introducing a cut-stem inoculation method for fast evaluation of sunflower resistance to Macrophomina phaseolina
The fast adaptation to different growing conditions of a fungus Macrophomina phaseolina , led to its becoming one of the sunflower ( Helianthus annuus ...
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Identification of sources of resistance to an Indian isolate causing Gummy stem blight in watermelon
Gummy stem blight caused by the fungus Stagonosporopsis cucurbitacearum (syn. Didymella bryoniae ), is a devastating disease of watermelon all over...
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Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance
Emerging evidence indicates that various cancers can gain resistance to targeted therapies by acquiring lineage plasticity. Although various genomic...
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Drug resistance in cancer therapy: the Pandora's Box of cancer stem cells
Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer relapse. This resistance mostly originates from rare, but...
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Paracrine secretion of IL8 by breast cancer stem cells promotes therapeutic resistance and metastasis of the bulk tumor cells
BackgroundBreast tumors consist of heterogeneous cellular subpopulations that differ in molecular properties and functional attributes. Cancer stem...
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Overlap** pathways involved in resistance against Sclerotinia stem rot in Brassica napus revealed through transcriptomic and metabolomic profiling
Brassica napus is one of the most important oilseed crops in the world, yet there are many challenges to its potential production. Sclerotinia...
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Genetic characterization and genome-wide association map** for stem rust resistance in spring bread wheat
BackgroundEmerging wheat stem rust races have become a major threat to global wheat production. Finding additional loci responsible for resistance to...
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Advances in ovarian tumor stem cells and therapy
Ovarian cancer is considered the most lethal among all gynecological malignancies due to its early metastatic dissemination, extensive spread, and...
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LncRNA PTPRG-AS1 maintains stem-cell-like features and promotes oxaliplatin resistance in colorectal cancer via regulating the miR-665 and STAT3 axis
BackgroundColorectal cancer (CRC) is one of the most prevalent malignant cancers worldwide. High recurrence and poor prognosis are caused by...
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Host Plant Resistance to Insect Pests in Maize
Maize, a potential global crop is attacked by a wide array of insect pests. Among them, spotted stem borer, pink stem borer, fall armyworm, and shoot...
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METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability
Oxaliplatin is the first-line regime for advanced gastric cancer treatment, while its resistance is a major problem that leads to the failure of...
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IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer
Immune checkpoint blockade (ICB)-based immunotherapy depends on functional tumour-infiltrating lymphocytes (TILs), but essential cytokines are less...
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Adult plant stem rust resistance in durum wheat Glossy Huguenot: map**, marker development and validation
Key messageAdult plant stem rust resistance locus, QSrGH.cs-2AL , was identified in durum wheat Glossy Huguenot and mendelised as Sr63 . Markers...
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Human menstrual blood-derived stem cells reverse sorafenib resistance in hepatocellular carcinoma cells through the hyperactivation of mitophagy
BackgroundSorafenib is a first-line drug targeting the RTK-MAPK signalling pathway used to treat advanced hepatocellular carcinoma (HCC). However,...
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Assessment of Sclerotinia Stem and Leaf Rot Resistance and its Association with Physical Strength Attributes in Brassicaceae with Special Emphasis on Brassica Juncea
The Brassicaceae family includes many economically important species that are grown worldwide and used mainly for vegetable oils. Sclerotinia stem...
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Genome assembly of Medicago truncatula accession SA27063 provides insight into spring black stem and leaf spot disease resistance
Medicago truncatula , model legume and alfalfa relative, has served as an essential resource for advancing our understanding of legume physiology,...
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Breeding Finger Millet for Biotic Stress Resistance
Finger millet (Eleusine coracana L.), commonly cultivated in countries with semiarid and tropical climate like India, can be a potential contributor...