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Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats
The temporal expression pattern of the circadian clock genes are known to be altered/attenuated with advance in age. Withania somnifera (WS)...
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Timed daily exercise remodels circadian rhythms in mice
Regular exercise is important for physical and mental health. An underexplored and intriguing property of exercise is its actions on the body’s 24 h...
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Anatomical Methods to Study the Suprachiasmatic Nucleus
The mammalian suprachiasmatic nucleus (SCN) functions as a master circadian pacemaker. In order to examine mechanisms by which it keeps time,...
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The RNA polymerase II subunit NRPB2 is required for indeterminate root development, cell viability, stem cell niche maintenance, and de novo root tip regeneration in Arabidopsis
The RNA polymerase II drives the biogenesis of coding and non-coding RNAs for gene expression. Here, we describe new roles for its second-largest...
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Palladium and platinum complexes based on pyridine bases induced anticancer effectiveness via apoptosis protein signaling in cancer cells
Palladium and platinum complexes, especially those that include cisplatin, can be useful chemotherapeutic drugs. Alternatives that have less adverse...
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Melatonin as a biological “time keeper” and its potential application in fish reproduction: a review
The biological rhythm is regulated through endogenous circadian clock and synchronizes with photoperiodic signal in an environmental light-dark...
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Identification of genomic loci conferring broad-spectrum resistance to multiple nematode species in exotic soybean accession PI 567305
Key MessageGenetic analysis identified a unique combination of major QTL for resistance to important soybean nematodes concurrently present in a...
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Electrophysiological Approaches to Studying the Suprachiasmatic Nucleus
In mammals, the part of the nervous system responsible for most circadian behavior can be localized to a bilaterally paired structure in the...
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Computational Analysis of PER2::LUC Imaging Data
Advances in imaging technology, combined with the development of bioluminescent reporters for core clock genes, has enabled the observation of...
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Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance
The anti-apoptotic protein HAX-1 has been proposed to modulate mitochondrial membrane potential, calcium signaling and actin remodeling. HAX-1 ...
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Acute In Vivo Multielectrode Recordings from the Mouse Suprachiasmatic Nucleus
The discovery of the suprachiasmatic nucleus (SCN) as the master mammalian pacemaker has since opened up a variety of alternative methods for...
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Impaired time-distance reconfiguration patterns in Alzheimer's disease: a dynamic functional connectivity study with 809 individuals from 7 sites
BackgroundThe dynamic functional connectivity (dFC) has been used successfully to investigate the dysfunction of Alzheimer's disease (AD) patients....
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Light Input to the Mammalian Circadian Clock
Circadian rhythms are 24-h cycles in physiology and behavior that occur in virtually all organisms. These processes are not simply driven by changes...
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Transcriptome analysis provides new insights into plants responses under phosphate starvation in association with chilling stress
BackgroundChilling temperature reduces the rate of photosynthesis in plants, which is more pronounced in association with phosphate (Pi) starvation....
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Genetic characterization of qSCN10 from an exotic soybean accession PI 567516C reveals a novel source conferring broad-spectrum resistance to soybean cyst nematode
Key messageThe qSCN10 locus with broad-spectrum SCN resistance was fine-mapped to a 379-kb region on chromosome 10 in soybean accession PI 567516C....
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Collection of Mouse Brain Slices for Bioluminescence Imaging of Circadian Clock Networks
Circadian rhythms in cellular function can be monitored in real time with bioluminescence imaging. In this approach, bioluminescence is produced by...
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The effect of heavy metals on thiocyanate biodegradation by an autotrophic microbial consortium enriched from mine tailings
AbstractBioremediation systems represent an environmentally sustainable approach to degrading industrially generated thiocyanate (SCN − ), with low...
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Suprachiasmatic nucleus-dependent and independent outputs driving rhythmic activity in hypothalamic and thalamic neurons
BackgroundDaily variations in mammalian physiology are under control of a central clock in the suprachiasmatic nucleus (SCN). SCN timing signals are...
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Studying Circadian Clock Entrainment by Hormonal Signals
In mammals, molecular circadian clocks not only exist in the suprachiasmatic nucleus (SCN) but in almost all organ systems. Intriguingly, tissue...
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Fine-map** and characterization of qSCN18, a novel QTL controlling soybean cyst nematode resistance in PI 567516C
Key messageThe
qSCN18 QTL from PI 56756C was confirmed and fine-mapped to improve soybean resistance to the SCN population HG Type 2.5.7 using...