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The complete chloroplast genome of Diplodiscus trichospermus and phylogenetic position of Brownlowioideae within Malvaceae
BackgroundMalvaceae is an economically important plant family of 4,225 species in nine subfamilies. Phylogenetic relationships among the nine...
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Rosace : a robust deep mutational scanning analysis framework employing position and mean-variance shrinkageDeep mutational scanning (DMS) measures the effects of thousands of genetic variants in a protein simultaneously. The small sample size renders...
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A comparative study reveals the relative importance of prokaryotic and eukaryotic proton pump rhodopsins in a subtropical marginal sea
Proton-pump rhodopsin (PPR) in marine microbes can convert solar energy to bioavailable chemical energy. Whereas bacterial PPR has been extensively...
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Complete chloroplast genome structural characterization of two Aerides (Orchidaceae) species with a focus on phylogenetic position of Aerides flabellata
BackgroundThe disputed phylogenetic position of Aerides flabellata Rolfe ex Downie, due to morphological overlaps with related species, was...
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Coupling of co-transcriptional splicing and 3’ end Pol II pausing during termination in Arabidopsis
BackgroundIn Arabidopsis, RNA Polymerase II (Pol II) often pauses within a few hundred base pairs downstream of the polyadenylation site, reflecting...
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Base-Editor-Mediated circRNA Knockout by Targeting Predominantly Back-Splice Sites
Back-splicing of eukaryotic exon(s) leads to the production of covalently closed circular RNAs (circRNAs). Generally, most circRNAs contain...
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Exploiting AGPase genes and encoded proteins to prioritize development of optimum engineered strains in microalgae towards sustainable biofuel production
Although ADP glucose pyrophosphorylase (AGPase), with two large subunits ( ls ) and two small subunits ( ss ), is a promising knockout target for...
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The complete chloroplast genome and phylogentic results support the species position of Swertia banzragczii and Swertia marginata (Gentianaceae) in Mongolia
BackgroundSwertia banzragczii and S. marginata are important medicinal species in Mongolia. However, their taxonomic positions and genetic...
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A new mechanism for a familiar mutation – bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement
BackgroundThe DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a...
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Application of genomic markers generated for ray-finned fishes in chondrichthyan Phylogenomics
Reconstructing a well-supported phylogenetic relationship among species is a prerequisite for biological and evolutionary researches. Chondrichthyes...
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High functional allelic diversity and copy number in both MHC classes in the common buzzard
BackgroundThe major histocompatibility complex (MHC), which encodes molecules that recognize various pathogens and parasites and initiates the...
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A novel single nucleotide mutation of TFL1 alters the plant architecture of Gossypium arboreum through changing the pre-mRNA splicing
Key messageA single nucleotide mutation from G to A at the 201st position changed the 5′ splice site and deleted 31 amino acids in the first exon of GaTFL1...
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Characterization and fine map** of a white stripe leaf mutant in rice
Leaf color affects the efficiency of photosynthesis, and leaf color mutants are important genetic materials for studying the mechanisms of...
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Genetic removal of the CH1 exon leads to the production of hypofunctional heavy chain-only IgG2a in rats
Despite great values in many applications, heavy chain-only antibodies (HcAbs) are naturally only produced in camelids and sharks, which are not easy...
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Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10
DOCK10, a guanine-nucleotide exchange factor (GEF) for Rho GTPases, represents the example of a gene that gives rise to alternative first exon mRNA...
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FLEP-seq: simultaneous detection of RNA polymerase II position, splicing status, polyadenylation site and poly(A) tail length at genome-wide scale by single-molecule nascent RNA sequencing
Elongation, splicing and polyadenylation are fundamental steps of transcription, and studying their coordination requires simultaneous monitoring of...
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Circular RNAs arising from synaptic host genes during human neuronal differentiation are modulated by SFPQ RNA-binding protein
BackgroundCircular RNA (circRNA) molecules, generated through non-canonical back-splicing of exon-exon junctions, have recently been implicated in...
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A missense mutation in TTC8/BBS8 affecting mRNA splicing in patients with non-syndromic retinitis pigmentosa
Splicing disruption is one type of mutation mechanism for disease-predisposing alleles. To date, less than 30 mutations in TTC8/BBS8 have been...
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Early Divergence of the C-Terminal Variable Region of Troponin T Via a Pair of Mutually Exclusive Alternatively Spliced Exons Followed by a Selective Fixation in Vertebrate Heart
Troponin T (TnT) is the thin filament anchoring subunit of troponin complex and plays an organizer role in the Ca 2+ -regulation of striated muscle...
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Screening for phenotypic outliers identifies an unusually low concentration of a β-lactoglobulin B protein isoform in bovine milk caused by a synonymous SNP
BackgroundMilk samples from 10,641 dairy cattle were screened by a mass spectrometry method for extreme concentrations of the A or B isoforms of the...
