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Biophysical characterization of the DNA binding motif of human phospholipid scramblase 1
Human phospholipid scramblase 1 (hPLSCR1) is a 37 kDa multi-compartmental protein, which was initially identified as a Ca 2+ -dependent phospholipid...
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Genome-wide analysis of the VQ motif-containing gene family and expression profiles during phytohormones and abiotic stresses in wheat (Triticum aestivum L.)
BackgroundVQ motif-containing (VQ) proteins are cofactors of transcriptional regulation that are widely involved in plant growth and development and...
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Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure
Hfq is a pleitropic actor that serves as stress response and virulence factor in the bacterial cell. To execute its multiple functions, Hfq assembles...
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Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α
Tripartite motif 8 (TRIM8) is an E3 ligase that plays dual roles in various tumor types. The biological effects and underlying mechanism of TRIM8 in...
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Chemerin attracts neutrophil reverse migration by interacting with C–C motif chemokine receptor-like 2
Neutrophil reverse migration (rM) is a recently identified phenomenon in which neutrophils migrate away from the inflammatory site back into the...
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BindVAE: Dirichlet variational autoencoders for de novo motif discovery from accessible chromatin
We present a novel unsupervised deep learning approach called BindVAE, based on Dirichlet variational autoencoders, for jointly decoding multiple TF...
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ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions
Molecular mimicry of host proteins by pathogens constitutes a strategy to hijack the host pathways. At present, there is no dedicated resource for...
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An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking
β-Coronaviruses such as SARS-CoV-2 hijack coatomer protein-I (COPI) for spike protein retrograde trafficking to the progeny assembly site in...
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Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling
The E3 ubiquitin ligase Tripartite-motif 3 (TRIM3) is known to play a crucial role in tumor suppression in various tumors through different...
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LBD18 and IAA14 antagonistically interact with ARF7 via the invariant Lys and acidic residues of the OPCA motif in the PB1 domain
Main conclusionLBD18 and IAA14 antagonistically interact with ARF7 through the electrostatic faces in the ARF7PB1 domain, modulating ARF7...
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Protein kinase CK2 phosphorylates a conserved motif in the Notch effector E(spl)-Mγ
Across metazoan animals, the effects of Notch signaling are mediated via the Enhancer of Split (E(spl)/HES) basic Helix–Loop–Helix–Orange (bHLH-O)...
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Genome-wide analysis of valine-glutamine motif-containing proteins related to abiotic stress response in cucumber (Cucumis sativus L.)
BackgroundCucumber ( Cucumis sativus L.) is one of the most important economic crops and is susceptible to various abiotic stresses. The...
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Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron
Studying the antibody response to SARS-CoV-2 informs on how the human immune system can respond to antigenic variants as well as other SARS-related...
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Modifying Amyloid Motif Aggregation Through Local Structure
Protein assembly into β-sheet-rich amyloid structures is a general biophysical phenomenon that has significant biological consequences, most notable...
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Relating spidroin motif prevalence and periodicity to the mechanical properties of major ampullate spider silks
Spider dragline fibers exhibit incredible mechanical properties, outperforming many synthetic polymers in toughness assays, and possess desirable...
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Genome-wide identification and expression analysis of the AT-hook Motif Nuclear Localized gene family in soybean
BackgroundSoybean is an important legume crop and has significant agricultural and economic value. Previous research has shown that the AT-Hook Motif...
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Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
BackgroundDysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and...
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Overexpression of VQ Motif-Containing Gene does not Affect Infection Rates of Potato with Potato Virus Y
Potato virus Y is a devastating pathogen affecting several crops including potato. Upon recognition of PVY, plants carrying PVY-resistance genes...
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D6PK plasma membrane polarity requires a repeated CXX(X)P motif and PDK1-dependent phosphorylation
D6 PROTEIN KINASE (D6PK) is a polarly localized plasma-membrane-associated kinase from Arabidopsis thaliana that activates polarly distributed...
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Constitutive expression of bZIP19 with the Zn sensor motif deleted in Arabidopsis leads to Zn-specific accumulation and no visible developmental penalty
AimsThe transcription factors bZIP19 and bZIP23 function as central regulators of the Zn deficiency response, and also as sensors of intracellular Zn...
