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Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid
The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In parallel, palmitic acid (PA) has...
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Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice
Itaconate, the product of the decarboxylation of cis -aconitate, regulates numerous biological processes. We and others have revealed itaconate as a...
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Weighted gene co-expression network analysis identified hub genes critical to fatty acid composition in Gushi chicken breast muscle
BackgroundThe composition and content of fatty acids in the breast muscle are important factors influencing meat quality. In this study, we...
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Association between fatty acid metabolism gene mutations and Mycobacterium tuberculosis transmission revealed by whole genome sequencing
BackgroundFatty acid metabolism greatly promotes the virulence and pathogenicity of Mycobacterium tuberculosis ( M.tb ). However, the regulatory...
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Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers
Aging manifests as progressive deteriorations in homeostasis, requiring systems-level perspectives to investigate the gradual molecular dysregulation...
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Fatty acid metabolism changes in association with neurobehavioral deficits in animal models of fetal alcohol spectrum disorders
Fetal alcohol spectrum disorders (FASD) show behavioral problems due to prenatal alcohol exposure (PAE). A previous study reports changes in gene...
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Microbial Biofactories: A Promising Approach Towards Sustainable Omega-3 Fatty Acid Production
Omega-3 fatty acids or polyunsaturated fatty acids known as are indispensable to human health and are more commonly referred to as āhealthy fats.ā...
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Phytohormonal impacts on fatty acid profiles in Chlorella vulgaris Beijerinck: endogenous identification and exogenous application of cytokinins and abscisic acid
Chlorella vulgaris has a high lipid content with potential for biofuel application. With a rapid growth cycle and ease of culture, it is well suited...
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Inhibiting fatty acid synthesis overcomes colistin resistance
Treating multidrug-resistant infections has increasingly relied on last-resort antibiotics, including polymyxins, for example colistin. As polymyxins...
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Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid Ī²-oxidation
Cellular metabolism influences immune cell function, with mitochondrial fatty acid Ī²-oxidation and oxidative phosphorylation required for multiple...
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Antioxidant profile, and fatty acids analysis of leaves of medicinal plant Piper chaba H. (Chuijhal): a promising source of antioxidant and fatty acids
Piper chaba Hunter belonging to the Piperaceae family, is mainly used as a spice in Bangladesh and West Bengal in India. It is an...
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Inhibition of autophagy impairs free fatty acid-induced excessive lipid accumulation in hepatocellular carcinoma and hepatic cells
Autophagy is a reparative life-sustaining process. Dysfunctions of autophagy play an important role in the progression of chronic liver diseases. The...
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The role of ApoE in fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions
BackgroundThe aim of this study was to investigate whether ischemia/hypoxia conditions induce fatty acid transport from neurons to astrocytes and...
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Genetic architecture and key regulatory genes of fatty acid composition in Gushi chicken breast muscle determined by GWAS and WGCNA
BackgroundFatty acids composition in poultry muscle is directly related to its tenderness, flavour, and juiciness, whereas its genetic mechanisms...
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Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion
The diffuse nature of Glioblastoma (GBM) tumors poses a challenge to current therapeutic options. We have previously shown that Acyl-CoA Binding...
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Menin orchestrates hepatic glucose and fatty acid uptake via deploying the cellular translocation of SIRT1 and PPARĪ³
BackgroundMenin is a scaffold protein encoded by the Men1 gene, which interacts with various transcriptional proteins to activate or repress...
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The role of fatty acid desaturase 2 in multiple tumor types revealed by bulk and single-cell transcriptomes
BackgroundPrevious studies have demonstrated the important role of fatty acid desaturase 2 (FADS2) in governing tumorigenesis and tumor metastasis....
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CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma
The oncogenic role of circRNA in cancers including esophageal cancer (EC) has been well studied. However, whether and how circRNAs are involved in...
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Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease
The response rate to obeticholic acid (OCA), a potential therapeutic agent for non-alcoholic fatty liver disease, is limited. This study demonstrated...
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High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis
BackgroundThe aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein...
