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Ci/Gli Phosphorylation by the Fused/Ulk Family Kinases
Hedgehog (Hh) signaling culminates in the conversion of the latent transcription factor Cubitus interruptus (Ci)/Gli from a repressor form (CiR/GliR)...
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Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets
Identifying genomic alterations of cancer proteins has guided the development of targeted therapies, but proteomic analyses are required to validate...
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In vitro anti-trypanosomal effect of ivermectin on Trypanosoma evansi by targeting multiple metabolic pathways
High cytotoxicity and increasing resistance reports of existing chemotherapeutic agents against T. evansi have raised the demand for novel, potent,...
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KinOrtho: a method for map** human kinase orthologs across the tree of life and illuminating understudied kinases
BackgroundProtein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and...
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Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication
BackgroundIn all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate...
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Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults
In a recent randomized, double-blind, placebo-controlled trial, we were able to demonstrate the superiority of a dietary supplement composed of...
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Mitogen-Activated Protein Kinase, Plants, and Heat Stress
Being sessile by nature, every plant is constantly exposed to myriad of both abiotic and biotic stresses in their immediate environment. All these...
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Isoptericola haloaureus sp. nov., a dimorphic actinobacterium isolated from mangrove sediments of southeast India, implicating biosaline agricultural significance through nitrogen fixation and salt tolerance genes
Strain MP-1014 T , an obligate halophilic actinobacterium, was isolated from the mangrove soil of Thandavarayancholanganpettai, Tamil Nadu, India. A...
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Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice
Senescent cell clearance is emerging as a promising strategy for treating age-related diseases. Senolytics are small molecules that promote the...
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SlCK2α as a novel substrate for CRL4 E3 ligase regulates fruit size through maintenance of cell division homeostasis in tomato
Main conclusionThis study unravels a novel regulatory module (CRL4-CK2α-CDK2) involving fruit size control by mediating cell division homeostasis...
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Role of Caspase-10-P13tBID axis in erythropoiesis regulation
Red blood cell production is negatively controlled by the rate of apoptosis at the stage of CFU-E/pro-erythroblast differentiation, depending on the...
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CSNK1D-mediated phosphorylation of HNRNPA2B1 induces miR-25-3p/miR-93-5p maturation to promote prostate cancer cell proliferation and migration through m6A-dependent manner
It has been reported that heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) is highly expressed in prostate cancer (PCa) and associated with...
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C1orf109 promotes malignant phenotype of liver cancer via wnt signaling pathway in a CK2-dependent manner
Chromosome 1 open reading frame 109 (C1orf09) is a protein whose expression pattern and biological function in humans, particularly in malignant...
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Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting
Mounting evidence indicates that immunogenic therapies engaging the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress favor...
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CK2α-mediated phosphorylation of GRP94 facilitates the metastatic cascade in triple-negative breast cancer
Distant metastasis is a significant hallmark affecting to the high death rate of patients with triple-negative breast cancer (TNBC). Thus, it is...
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Genome-wide identification, evolutionary estimation and functional characterization of two cotton CKI gene types
BackgroundCasein kinase I (CKI) is a kind of serine/threonine protein kinase highly conserved in plants and animals. Although molecular function of...
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Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis
Melanoma is the most aggressive among all types of skin cancers. The current strategies against melanoma utilize BRAF V600E , as a focal point for...
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Thermal proteome profiling unveils protein targets of deoxycholic acid in living neuronal cells
Bile acids, synthesized in the liver and modified by the gut microbiota, play vital roles in various physiological processes. The dysregulation of...
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Glyoxalase I activity affects Arabidopsis sensitivity to ammonium nutrition
Key messageElevated methylglyoxal levels contribute to ammonium-induced growth disorders in Arabidopsis thaliana . Methylglyoxal detoxification...
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The long transcript of lncRNA TMPO-AS1 promotes bone metastases of prostate cancer by regulating the CSNK2A1/DDX3X complex in Wnt/β-catenin signaling
The second most common male cancer is prostate cancer (PCa), which has a high tendency for bone metastasis. Long non-coding RNAs, including TMPO-AS1 ,...
