Search
Search Results
-
Improved detection of clinically relevant fusion transcripts in cancer by machine learning classification
BackgroundGenomic rearrangements in cancer cells can create fusion genes that encode chimeric proteins or alter the expression of coding and...
-
A hybrid metaheuristic-deep learning technique for the pan-classification of cancer based on DNA methylation
BackgroundDNA Methylation is one of the most important epigenetic processes that are crucial to regulating the functioning of the human genome...
-
Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy
Despite producing a panoply of potential cancer-specific targets, the proteogenomic characterization of human tumors has yet to demonstrate value for...
-
Molecular classification of urothelial bladder carcinoma
Urothelial bladder carcinoma (UC) ranks among the top ten most commonly diagnosed cancers worldwide on an annual basis. The standardized...
-
Multi-class Cancer Classification of Whole Slide Images Through Transformer and Multiple Instance Learning
Whole slide images (WSIs) are high-resolution and lack localized annotations, whose classification can be treated as a multiple instance learning...
-
DeepAutoGlioma: a deep learning autoencoder-based multi-omics data integration and classification tools for glioma subty**
Background and objectiveThe classification of glioma subtypes is essential for precision therapy. Due to the heterogeneity of gliomas, the...
-
Digital spatial profiling of the microenvironment of muscle invasive bladder cancer
Muscle invasive bladder cancer (MIBC) is a molecularly diverse disease with varied clinical outcomes. Molecular studies typically employ bulk...
-
Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer
Despite the uniform mortality in pancreatic adenocarcinoma (PDAC), clinical disease heterogeneity exists with limited genomic differences. A highly...
-
Genetic Testing in Endometrial Cancer
Endometrial carcinoma is one of the most commonly occurring gynecological malignancies. It is diagnosed mostly at the age of 50, yet 5% of cases...
-
YAP1 expression is associated with survival and immunosuppression in small cell lung cancer
Immunotherapy is considered a major breakthrough in the treatment of small cell lung cancer (SCLC), although its anti-tumor efficacy is limited. With...
-
Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation
BackgroundAs one of the most common malignancies, esophageal cancer has two subtypes, squamous cell carcinoma and adenocarcinoma, arising from...
-
Adap-BDCM: Adaptive Bilinear Dynamic Cascade Model for Classification Tasks on CNV Datasets
Copy number variation (CNV) is an essential genetic driving factor of cancer formation and progression, making intelligent classification based on...
-
GTM-decon: guided-topic modeling of single-cell transcriptomes enables sub-cell-type and disease-subtype deconvolution of bulk transcriptomes
Cell-type composition is an important indicator of health. We present Guided Topic Model for deconvolution (GTM-decon) to automatically infer...
-
Drug-Resistant Epithelial Ovarian Cancer: Current and Future Perspectives
Epithelial ovarian cancer (EOC) is a complex disease with diverse histological subtypes, which, based on the aggressiveness and course of disease...
-
Multiomics-Based Tensor Decomposition for Characterizing Breast Cancer Heterogeneity
Breast cancer is heterogeneous and consists of intrinsic components with various alterations. Combining multiple genomic sources to identify the...
-
Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant
Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly...
-
Combined PD-1/PD-L1 and tumor-infiltrating immune cells redefined a unique molecular subtype of high-grade serous ovarian carcinoma
BackgroundHigh-grade serous ovarian carcinoma is highly heterogeneous, and although many studies have been conducted to identify high-grade serous...
-
Proteomic analysis of breast cancer based on immune subtypes
BackgroundImmunotherapy is applied to breast cancer to resolve the limitations of survival gain in existing treatment modalities. With immunotherapy,...
-
Pan-cancer integrative analysis of whole-genome De novo somatic point mutations reveals 17 cancer types
BackgroundThe advent of high throughput sequencing has enabled researchers to systematically evaluate the genetic variations in cancer, identifying...
-
Single-cell transcriptomics reveals cellular heterogeneity and molecular stratification of cervical cancer
Cervical cancer (CC) is the most common gynecological malignancy, whose cellular heterogeneity has not been fully understood. Here, we performed...
