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GMP-Compliant Mesenchymal Stem Cell-Derived Exosomes for Cell-Free Therapy in Cancer
Cancer is categorized as one of the life-threatening disease in the world, which has recently been associated with a significant increase in the...
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Non-stem Cell Mediated Tissue Regeneration and Repair
Regrowth and replacement are two basic responses of the body to any injury. While regrowth is generally attributed to stem cells, and replacement or...
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DMRTA2 supports glioma stem-cell mediated neovascularization in glioblastoma
Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Due to its fast proliferation, diffusive growth and therapy resistance...
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Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
BackgroundNatural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral...
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Forkhead box O proteins: steering the course of stem cell fate
Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately...
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Exploring distinct properties of endometrial stem cells through advanced single-cell analysis platforms
The endometrium is a dynamic tissue that undergoes cyclic changes in response to ovarian hormones during the menstrual cycle. These changes are...
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MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning
BackgroundThe enrichment of peri-cancerous adipose tissue is a distinctive feature of colorectal cancer (CRC), accelerating disease progression and...
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Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report
National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving...
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Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies
Exosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. Exosomes originating from inflammatory or...
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Morbid Cell Status and Donor Age Significantly Alter Mesenchymal Stem Cell Functionality and Reparability
Bone marrow (BM)-derived mesenchymal stem cells (MSCs) differentiate into specialized tissues, including cardiomyocytes, endothelial cells, and...
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In vitro anti-leukemic effect of Wharton’s jelly derived mesenchymal stem cells
BackgroundMesenchymal stem cells (MSCs) have the ability to self-renew and are multi-potent. They are a primary candidate for cell-based therapy due...
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Tumor Microenvironment: A Niche for Cancer Stem Cell Immunotherapy
Tumorigenic Cancer Stem Cells (CSCs), often called tumor-initiating cells (TICs), represent a unique subset of cells within the tumor milieu. They...
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Factors Defining Human Adipose Stem/Stromal Cell Immunomodulation in Vitro
Human adipose tissue-derived stem/stromal cells (hASCs) are adult multipotent mesenchymal stem/stromal cells with immunomodulatory capacities. Here,...
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Tissue memory relies on stem cell priming in distal undamaged areas
Epithelial cells that participated in wound repair elicit a more efficient response to future injuries, which is believed to be locally restricted....
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Gastric Cancer Mesenchymal Stem Cells Trigger Endothelial Cell Functional Changes to Promote Cancer Progression
Our previous studies have highlighted the pivotal role of gastric cancer mesenchymal stem cells (GCMSCs) in tumor initiation, progression, and...
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Cancer stem cells: an insight into the development of metastatic tumors and therapy resistance
The term “cancer stem cells” (CSCs) refers to cancer cells that exhibit traits parallel to normal stem cells, namely the potential to give rise to...
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Dual impacts of mesenchymal stem cell-derived exosomes on cancer cells: unravelling complex interactions
Mesenchymal stem cells (MSCs) are multipotent, self-renewing stromal cells found in a variety of adult tissues. MSCs possess a remarkable ability to...
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Single-cell transcriptomic analyses of tumor microenvironment and molecular reprograming landscape of metastatic laryngeal squamous cell carcinoma
Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor with a high probability of metastasis. The tumor microenvironment (TME) plays a...
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CCT2 prevented β-catenin proteasomal degradation to sustain cancer stem cell traits and promote tumor progression in epithelial ovarian cancer
BackgroundEpithelial ovarian cancer (EOC) is featured by rapid progression and dismal outcomes clinically. Chaperonin Containing TCP1 Subunit 2...
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Morbid Cell Status and Donor Age Significantly Alter Mesenchymal Stem Cell Functionality and Reparability
Bone marrow (BM)-derived mesenchymal stem cells (MSCs) differentiate into specialized tissues, including cardiomyocytes, endothelial cells, and...