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XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
XIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X chromosome inactivation (XCI) in placental mammals, yet it...
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Molecular characterization of recombinant citrus yellow mosaic badnavirus infecting Coorg mandarin exhibiting yellow mosaic disease symptoms in high humid tropic region of Western Ghats
The citrus yellow mosaic badnavirus (CMBV) is one of the most important viruses causing yellowing and declining in different Citrus species. The...
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MYC phase separation selectively modulates the transcriptome
Dysregulation and enhanced expression of MYC transcription factors (TFs) including MYC and MYCN contribute to the majority of human cancers. For...
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A unifying model for membrane protein biogenesis
α-Helical integral membrane proteins comprise approximately 25% of the proteome in all organisms. The membrane proteome is highly diverse, varying in...
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XPD stalled on cross-linked DNA provides insight into damage verification
The superfamily 2 helicase XPD is a central component of the general transcription factor II H (TFIIH), which is essential for transcription and...
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Vaccine approaches and treatment aspects against Crimean Congo hemorrhagic fever
Crimean-Congo hemorrhagic fever [CCHF] is a severe infectious viral disease caused by a tick borne virus which can lead to fatal hemorrhagic disease...
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Prevalence of bovine herpes virus-1 among reproductive disorders in cattle and buffaloes in Punjab region of India
Bovine Herpes Virus (BHV-1) is a virus prevalent among cattle and buffaloes which accounts for considerable reproductive failures. This study was...
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Immunomodulatory effects of cannabinoids against viral infections: a review of its potential use in SARS-CoV2 infection
The COVID-19 pandemic is a global health crisis affecting millions of people worldwide. Along with vaccine development, there is also a priority to...
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p38-MAPK is prerequisite for the synthesis of SARS-CoV-2 protein
The inhibition of p38 mitogen-activated protein kinase (p38-MAPK) by small molecule chemical inhibitors was previously shown to impair severe acute...
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Structural insights into PPP2R5A degradation by HIV-1 Vif
HIV-1 Vif recruits host cullin-RING-E3 ubiquitin ligase and CBFβ to degrade the cellular APOBEC3 antiviral proteins through diverse interactions....
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Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification
The mouse and human embryo gradually loses totipotency before diversifying into the inner cell mass (ICM, future organism) and trophectoderm (TE,...
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TET activity safeguards pluripotency throughout embryonic dormancy
Dormancy is an essential biological process for the propagation of many life forms through generations and stressful conditions. Early embryos of...
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eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition
Eukaryotic translation initiation factor (eIF)4A—a DEAD-box RNA-binding protein—plays an essential role in translation initiation. Recent reports...
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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
Channel enzymes represent a class of ion channels with enzymatic activity directly or indirectly linked to their channel function. We investigated a...
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To slide or not to slide: key role of the hexasome in chromatin remodeling revealed
Hexasomes are non-canonical nucleosomes that package DNA with six instead of eight histones. First discovered 40 years ago as a consequence of...
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RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth
NADH/NAD + redox balance is pivotal for cellular metabolism. Systematic identification of NAD(H) redox regulators, although currently lacking, would...
