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Investigating the impact of poverty on mental illness in the UK Biobank using Mendelian randomization
It is unclear whether poverty and mental illness are causally related. Using UK Biobank and Psychiatric Genomic Consortium data, we examined evidence...
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LRIG1 controls proliferation of adult neural stem cells by facilitating TGFβ and BMP signalling pathways
Adult Neural Stem Cells (aNSCs) in the ventricular-subventricular zone (V-SVZ) are largely quiescent. Here, we characterize the mechanism underlying...
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Methylglyoxal detoxification pathway in barley genotypes after infection with Bipolaris sorokiniana
The present investigation was carried out to study the leaf composition and methylglyoxal pathway in four barley genotypes on infection with Bipolaris...
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Bisphenol S causes excessive estrogen synthesis by activating FSHR and the downstream cAMP/PKA signaling pathway
Estrogen excess in females has been linked to a diverse array of chronic and acute diseases. Emerging research shows that exposure to estrogen-like...
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Emerging roles of CAR-NK cell therapies in tumor immunotherapy: current status and future directions
Cancer immunotherapy harnesses the body’s immune system to combat malignancies, building upon an understanding of tumor immunosurveillance and immune...
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Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease
Recent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal...
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LINC01133 promotes pancreatic ductal adenocarcinoma epithelial–mesenchymal transition mediated by SPP1 through binding to Arp3
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment methods. Long non-coding RNAs (lncRNAs) have been found involved...
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Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt
BackgroundThe emergence of multi-drug-resistant Klebsiella pneumoniae (MDR-KP) represents a serious clinical health concern. Antibiotic resistance...
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Two-dimensional high-throughput on-cell screening of immunoglobulins against broad antigen repertoires
Identifying high-affinity antibodies in human serum is challenging due to extremely low number of circulating B cells specific to the desired...
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Glutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK
Bcr-Abl transformation leads to chronic myeloid leukemia (CML). The acquirement of T315I mutation causes tyrosine kinase inhibitors (TKI) resistance....
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Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Protein folding in vivo begins during synthesis on the ribosome and is modulated by molecular chaperones that engage the nascent polypeptide. How...
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Myofibroblasts derived type V collagen promoting tissue mechanical stress and facilitating metastasis and therapy resistance of lung adenocarcinoma cells
Lung cancer is a leading cause of cancer-related mortality globally, with a dismal 5-year survival rate, particularly for Lung Adenocarcinoma (LUAD)....
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Spores of Clostridioides difficile are toxin delivery vehicles
Clostridioides difficile causes a wide range of intestinal diseases through the action of two main cytotoxins, TcdA and TcdB. Ingested spores...
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Blood protein assessment of leading incident diseases and mortality in the UK Biobank
The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein...
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Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection
Emerging evidence suggests that neurological and other post-acute sequelae of COVID-19 can persist beyond or develop following SARS-CoV-2 infection....
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Nitric oxide brings innate immune resistance to M. tuberculosis infection among high-risk household contacts of pulmonary tuberculosis patients
Nitric oxide (NO) and iNOS are crucial host factors in innate immunity against intracellular pathogens. However, the role of NO in Mycobacterium...
