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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
The mitochondrial chaperonin, mitochondrial heat shock protein 60 (mtHsp60), promotes the folding of newly imported and transiently misfolded...
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Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy
During formation of the transcription-competent open complex (RPo) by bacterial RNA polymerases (RNAPs), transient intermediates pile up before...
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Alterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients
BackgroundPatients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared...
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Predicting glycan structure from tandem mass spectrometry via deep learning
Glycans constitute the most complicated post-translational modification, modulating protein activity in health and disease. However, structural...
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Taxonomic and phenotypic analysis of bifidobacteria isolated from IBD patients as potential probiotic strains
BackgroundInflammatory Bowel Diseases (IBD) are a major public health issue with unclear aetiology. Changes in the composition and functionality of...
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Lipopeptides from Bacillus velezensis ZLP-101 and their mode of action against bean aphids Acyrthosiphon pisum Harris
BackgroundNatural products are important sources for the discovery of new biopesticides to control the worldwide destructive pests Acyrthosiphon...
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Gut fungi of black-necked cranes (Grus nigricollis) respond to dietary changes during wintering
BackgroundMigratory birds exhibit heterogeneity in foraging strategies during wintering to cope with environmental and migratory pressures, and gut...
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Mating Disruption of a Flighted Spongy Moth, Lymantria Dispar Japonica (Motchulsky) in Japan
Mating disruption of a flighted spongy moth, Lymantria dispar japonica (Motchulsky)(Lepidoptera: Lymantridae), with a synthetic version of its sex...
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Develo** Oak Buds Produce Volatile Emissions in Response to Herbivory by Freshly Hatched Caterpillars
Plant responses to damage by insectivorous herbivores are well-documented in mature leaves. The resulting herbivore-induced plant volatiles (HIPVs)...
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Kinetics of dengue viremia and its association with disease severity: an ambispective study
BackgroundDengue virus (DENV) infection is an important public health problem and causes significant morbidity and mortality. DENV typically causes a...
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Molecular characterization and epidemiological investigation of colistin resistance in carbapenem-resistant Klebsiella pneumoniae in a tertiary care hospital in Tehran, Iran
BackgroundCarbapenemase-producing Klebsiella pneumoniae (CRKP) presents a significant challenge to antimicrobial therapy, especially when compounded...
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Metabolomics analysis of the lactobacillus plantarum ATCC 14917 response to antibiotic stress
BackgroundLactobacillus plantarum has been found to play a significant role in maintaining the balance of intestinal flora in the human gut....
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Living in mangroves: a syntrophic scenario unveiling a resourceful microbiome
BackgroundMangroves are complex and dynamic coastal ecosystems under frequent fluctuations in physicochemical conditions related to the tidal regime....
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Mining biosynthetic gene clusters in Paenibacillus genomes to discover novel antibiotics
BackgroundBacterial antimicrobial resistance poses a severe threat to humanity, necessitating the urgent development of new antibiotics. Recent...
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Inhibitory activity of bacterial lipopeptides against Fusarium oxysporum f.sp. Strigae
This study investigated the influence of bacterial cyclic lipopeptides (LP; surfactins, iturins, fengycins) on microbial interactions. The objective...
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Antibacterial activity and mechanisms of D-3263 against Staphylococcus aureus
Multi-drug-resistant Staphylococcus aureus infections necessitate novel antibiotic development. D-3263, a transient receptor potential melastatin...
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Characterization and genetic analysis of extensively drug-resistant hospital acquired Pseudomonas aeruginosa isolates
BackgroundThe incidence of hospital-acquired infections in extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) has been increasing worldwide...
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Molecular prevalence and genotypes of Enterocytozoon bieneusi in cancer patients under chemotherapy in Aegean region of Türkiye
BackgroundEnterocytozoon bieneusi is the most common species found in humans. Although E. bieneusi has been investigated in humans, genotype profile...
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Prebiotic fibre mixtures counteract the manifestation of gut microbial dysbiosis induced by the chemotherapeutic 5-Fluorouracil (5-FU) in a validated in vitro model of the colon
Background5-Fluorouracil (5-FU) is used as an antineoplastic agent in distinct cancer types. Increasing evidence suggests that the gut microbiota...
