Search
Search Results
-
Gapr for large-scale collaborative single-neuron reconstruction
Whole-brain analysis of single-neuron morphology is crucial for unraveling the complex structure of the brain. However, large-scale neuron...
-
Gut microbiota Parabacteroides distasonis enchances the efficacy of immunotherapy for bladder cancer by activating anti-tumor immune responses
ObjectiveBladder cancer(BCa) was a disease that seriously affects patients’ quality of life and prognosis. To address this issue, many researches...
-
Impact of captivity and natural habitats on gut microbiome in Epinephelus akaara across seasons
BackgroundThe gut microbiota significantly influences the health and growth of red-spotted grouper ( Epinephelus akaara ), a well-known commercial...
-
Formic acid sandwich method is well-suited for filamentous fungi identification and improves turn around time using Zybio EXS2600 mass spectrometry
ObjectivesMatrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is extensively employed for the identification...
-
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers
The canonical BRG/BRM-associated factor (cBAF) complex is essential for chromatin opening at enhancers in mammalian cells. However, the nature of the...
-
-
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding RNA (lncRNA) has key roles in regulating transcription, splicing,...
-
-
fENko-Kae01 is a flagellum-specific jumbo phage infecting Klebsiella aerogenes
BackgroundKlebsiella aerogenes is an opportunistic pathogen that causes a wide variety of infections. Due to the rising problem of antibiotic...
-
Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing
The development of precise RNA-editing tools is essential for the advancement of RNA therapeutics. CRISPR (clustered regularly interspaced short...
-
Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
The mitochondrial chaperonin, mitochondrial heat shock protein 60 (mtHsp60), promotes the folding of newly imported and transiently misfolded...
-
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy
During formation of the transcription-competent open complex (RPo) by bacterial RNA polymerases (RNAPs), transient intermediates pile up before...
-
Alterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients
BackgroundPatients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared...
-
Predicting glycan structure from tandem mass spectrometry via deep learning
Glycans constitute the most complicated post-translational modification, modulating protein activity in health and disease. However, structural...
-
Taxonomic and phenotypic analysis of bifidobacteria isolated from IBD patients as potential probiotic strains
BackgroundInflammatory Bowel Diseases (IBD) are a major public health issue with unclear aetiology. Changes in the composition and functionality of...
-
Lipopeptides from Bacillus velezensis ZLP-101 and their mode of action against bean aphids Acyrthosiphon pisum Harris
BackgroundNatural products are important sources for the discovery of new biopesticides to control the worldwide destructive pests Acyrthosiphon...
-
Gut fungi of black-necked cranes (Grus nigricollis) respond to dietary changes during wintering
BackgroundMigratory birds exhibit heterogeneity in foraging strategies during wintering to cope with environmental and migratory pressures, and gut...
-
Mating Disruption of a Flighted Spongy Moth, Lymantria Dispar Japonica (Motchulsky) in Japan
Mating disruption of a flighted spongy moth, Lymantria dispar japonica (Motchulsky)(Lepidoptera: Lymantridae), with a synthetic version of its sex...
-
Develo** Oak Buds Produce Volatile Emissions in Response to Herbivory by Freshly Hatched Caterpillars
Plant responses to damage by insectivorous herbivores are well-documented in mature leaves. The resulting herbivore-induced plant volatiles (HIPVs)...
