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The Impact of Astrocytes and Endothelial Cells on Glioblastoma Stemness Marker Expression in Multicellular Spheroids
IntroductionGlioblastoma multiforme (GBM), the most common primary brain tumor in adults, is extremely malignant and lethal. GBM tumors are highly...
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3D-Printed electrochemical sensor-integrated transwell systems
This work presents a 3D-printed, modular, electrochemical sensor-integrated transwell system for monitoring cellular and molecular events in situ...
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Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota–gut–brain axis
The microbiota–gut–brain axis (MGBA) has emerged as a key prospect in the bidirectional communication between two major organ systems: the brain and...
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Advances in modeling permeability and selectivity of the blood-brain barrier using microfluidics
The blood-brain barrier (BBB) protects the brain by actively allowing the entry of ions and nutrients while limiting the passage of from toxins and...
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Human Atrial Cardiac Microtissues for Chamber-Specific Arrhythmic Risk Assessment
IntroductionAlthough atrial fibrillation is the most prevalent disorder of electrical conduction, the mechanisms behind atrial arrhythmias remain...
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Hepatic Vascular Network Construction Using Magnetic Fields
Without perfusable vascular networks, three-dimensional tissues populated with cells cannot maintain a living condition. To construct 3D tissues, a... -
Engineering brain-on-a-chip platforms
The increasing prevalence of neurological and psychiatric diseases, such as Alzheimer disease and schizophrenia, necessitates the development of new...
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Recent advances in the development of in vitro liver models for hepatotoxicity testing
Liver injury is a common cause of drug approval withdrawal during drug development, pre-clinical research, and clinical treatment. If not properly...
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Biomethanation of Syngas by Enriched Mixed Anaerobic Consortia in Trickle Bed Reactors
Two identical trickle-bed reactor setups were designed and operated under mesophilic conditions and atmospheric pressure, without pH control, for the...
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3D bioprinting for cell culture and tissue fabrication
Three-dimensional (3D) bioprinting is a computer-assisted technology which precisely controls spatial position of biomaterials, growth factors and...