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Controllable fusion of multicellular spheroids using acoustofluidics
3D self-assembly of biological tissues is essential for organ development, tissue engineering, transplantation, and organ regeneration. Although...
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Electrostatic levitations of anisotropic dielectric oblate and prolate spheroids
The paper presents analytical approach to electrostatic field for dielectric spheroids problem. For both oblate and prolate spheroids fields...
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Using pipette tips to readily generate spheroids comprising single or multiple cell types
Three-dimensional (3D) cell culture methods have been validated that can replicate the tumor environment in vivo to a large extent, providing an...
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Uniform sized cancer spheroids production using hydrogel-based droplet microfluidics: a review
Three-dimensional (3D) cell culture models have been extensively utilized in various mechanistic studies as well as for drug development studies as...
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Tissue engineering RPE sheet derived from hiPSC-RPE cell spheroids supplemented with Y-27632 and RepSox
BackgroundRetinal pigment epithelium (RPE) cell therapy is a promising way to treat many retinal diseases. However, obtaining transplantable RPE...
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Irradiated Mammary Spheroids Elucidate Mechanisms of Macrophage-Mediated Breast Cancer Recurrence
IntroductionWhile most patients with triple negative breast cancer receive radiation therapy to improve outcomes, a significant subset of patients...
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Non-destructive Analysis of Spheroids Using Artificial Intelligence: Preliminary Study of Convolutional Neural Networks Performance
With an increasing research of new 3D cell cultures, specially spheroids, Convolutional Neural Networks (CNNs) have proven their potential for...
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On the behavior of prolate spheroids in a standing surface acoustic wave field
The active manipulation of particle and cell trajectories in fluids by high-frequency standing surface acoustic waves (sSAW) allows to separate...
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Construction of dynamic Green’s function for an infinite acoustic field with multiple prolate spheroids
The acoustic pressure of an unbounded acoustic field with multiple prolate spheroids with the Robin boundary conditions subjected to a time-harmonic...
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Spheroids, organoids and kidneys-on-chips: how complex human cellular models have assisted in the study of kidney disease and renal ciliopathies
Kidney disease is one of the leading causes of morbidity worldwide, emphasizing the importance for physiologically accurate disease models. With most...
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Modeling and measuring glucose diffusion and consumption by colorectal cancer spheroids in hanging drops using integrated biosensors
As 3D in vitro tissue models become more pervasive, their built-in nutrient, metabolite, compound, and waste gradients increase biological relevance...
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Exploring Different Convolutional Neural Networks Architectures to Identify Cells in Spheroids
The cultivation of cells in 3D has gained more interest in research once 3D architecture can be closer to full cell physiological functionality. The...
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Double emulsion-pretreated microwell culture for the in vitro production of multicellular spheroids and their in situ analysis
Multicellular spheroids have served as a promising preclinical model for drug efficacy testing and disease modeling. Many microfluidic technologies,...
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The Impact of Astrocytes and Endothelial Cells on Glioblastoma Stemness Marker Expression in Multicellular Spheroids
IntroductionGlioblastoma multiforme (GBM), the most common primary brain tumor in adults, is extremely malignant and lethal. GBM tumors are highly...
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An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow
AbstractOne of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at...
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A microfluidic platform for cultivating ovarian cancer spheroids and testing their responses to chemotherapies
There is increasing interest in utilizing in vitro cultures as patient avatars to develop personalized treatment for cancer. Typical cultures utilize...
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Hydrogel-based sealed microchamber arrays for rapid medium exchange and drug testing of cell spheroids
Culturing cell spheroids in microchamber arrays is a widely used method in regenerative medicine and drug discovery while it requires laborious...
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Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy
Despite their simplicity, monolayer cell cultures are not able to accurately predict drug behavior in vivo due to their inability to accurately mimic...
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Expediency of Using a Physical and Mathematical Model in Cell Engineering
In order to improve the efficiency of the methods of multicellular objects cryopreservation in the presented work it is proposed to use the method of...
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Construction and applications of the EOMA spheroid model of Kaposiform hemangioendothelioma
BackgroundKaposiform hemangioendothelioma (KHE) is a rare intermediate vascular tumor with unclear pathogenesis. Recently, three dimensional (3D)...
