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Construction of microfluidic blood–brain barrier model assisted by 3D coculture on cellulose fiber
In this study, we fabricated a microfluidic device to mimic the human blood–brain barrier (BBB) in vitro, comprising a cellulose fiber membrane...
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Generating an In Vitro Gut Model with Physiologically Relevant Biophysical Mucus Properties
IntroductionGastrointestinal (GI) in vitro models have received lasting attention as an effective tool to model drug and nutrient absorption, study...
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3D free-assembly modular microfluidics inspired by movable type printing
Reconfigurable modular microfluidics presents an opportunity for flexibly constructing prototypes of advanced microfluidic systems. Nevertheless, the...
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3D-bioprinted cholangiocarcinoma-on-a-chip model for evaluating drug responses
Cholangiocarcinoma (CCA) is characterized by heterogeneous mutations and a refractory nature. Thus, the development of a model for effective drug...
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The Impact of Astrocytes and Endothelial Cells on Glioblastoma Stemness Marker Expression in Multicellular Spheroids
IntroductionGlioblastoma multiforme (GBM), the most common primary brain tumor in adults, is extremely malignant and lethal. GBM tumors are highly...
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Single-Cell Cultivation Utilizing Microfluidic Systems
Single-cell analysis is essential to deepen our understanding of cellular and subcellular cells at a single-cell level. Single-cell mechanism can be...
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Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments
Hypoxia is a condition where tissue oxygen levels fall below normal levels. In locally induced hypoxia due to blood vessel blockage, oxygen delivery...
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Coaxial bioprinted microfibers with mesenchymal stem cells for glioma microenvironment simulation
Due to their special anatomical and physiological features, central nervous system diseases still presented challenges, despite the fact that some...
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Microfluidic Culture Platforms in Neuroscience Research
Over the past few decades, micromachined chips such as microfluidic systems are making a big impact on neuroscience research and the industry due to...
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Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota–gut–brain axis
The microbiota–gut–brain axis (MGBA) has emerged as a key prospect in the bidirectional communication between two major organ systems: the brain and...
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Perfusion Bioreactors for Prevascularization Strategies in Cardiac Tissue Engineering
Cardiac tissue engineering is currently being pursued with three different applications in mind: drug safety screening, disease modeling, and cardiac...
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Polymeric and biological membranes for organ-on-a-chip devices
Membranes are fundamental elements within organ-on-a-chip (OOC) platforms, as they provide adherent cells with support, allow nutrients (and other...
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Fabrication of 3D-printed molds for polydimethylsiloxane-based microfluidic devices using a liquid crystal display-based vat photopolymerization process: printing quality, drug response and 3D invasion cell culture assays
Microfluidic platforms enable more precise control of biological stimuli and environment dimensionality than conventional macroscale cell-based...
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Dissolvable temporary barrier: a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models
A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional (3D) tissue models in vitro, which are also...
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Study of High Molecular Weight Hemicelluloses Recovered from Black Spruce Mill Waste for Potential Value-Added Applications in Foods
The aim of this study was to characterize the high molecular weight fraction (> 10,000 g/mol) of black spruce sawdust water extracts obtained by...
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Patient-derived pancreatic cancer-on-a-chip recapitulates the tumor microenvironment
The patient population suffering from pancreatic ductal adenocarcinoma (PDAC) presents, as a whole, with a high degree of molecular tumor...
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Microfluidic high-throughput 3D cell culture
High-throughput 3D microfluidic cell culture systems can be designed to model aspects of human tissues and organs and may thus serve as non-clinical...
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Tissue engineering in age-related macular degeneration: a mini-review
Age-related macular degeneration (AMD) is a progressive, degenerative disease of the macula, leading to severe visual loss in the elderly population....
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In vitro recellularization of decellularized bovine carotid arteries using human endothelial colony forming cells
BackgroundMany patients suffering from peripheral arterial disease (PAD) are dependent on bypass surgery. However, in some patients no suitable...
