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Systematic simulation of tumor cell invasion and migration in response to time-varying rotating magnetic field
Cancer invasion and migration play a pivotal role in tumor malignancy, which is a major cause of most cancer deaths. Rotating magnetic field (RMF),...
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Sevoflurane Suppresses the Proliferation, Migration and Invasion of Colorectal Cancer Through Regulating Circ_0000423/miR-525-5p/SGPP1 Network
IntroductionSevoflurane (SEV) has been shown to inhibit the malignant progression in many cancers, including colorectal cancer (CRC). However, it is...
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A transcription factor that promotes proliferation, migration, invasion, and epithelial–mesenchymal transition of ovarian cancer cells and its possible mechanisms
BackgroundOvarian cancer is one of the most common gynecological malignancies with the high morbidity and mortality. This study was aimed to explore...
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LINC00852 Regulates Cell Proliferation, Invasion, Migration and Apoptosis in Hepatocellular Carcinoma Via the miR-625/E2F1 Axis
ObjectiveThis study investigates the function and regulatory mechanism of lncRNA LINC00852 in hepatocellular carcinoma (HCC) cells.
Methods ...
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A Review of Fabrication and Applications of Confined Microchannels for Cell Migration Assay
Cell migration is an essential process in a number of physiological and pathological events, and known to be modulated by external microenvironment...
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Do Cancer Cells Collaborate During Metastasis?
We consider a model for cell deformation and cellular forces that are exerted on the immediate environment. This model is applied to the...
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On a mathematical model for cancer invasion with repellent pH-taxis and nonlocal intraspecific interaction
Starting from a mesoscopic description of cell migration and intraspecific interactions, we obtain by upscaling an effective reaction–diffusion–taxis...
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Adipose Stroma Accelerates the Invasion and Escape of Human Breast Cancer Cells from an Engineered Microtumor
IntroductionApproximately 20–25% of human breast tumors are found within an adipose, rather than fibrous, stroma. Adipose stroma is associated with...
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Glioblastoma Cells Use an Integrin- and CD44-Mediated Motor-Clutch Mode of Migration in Brain Tissue
PurposeGlioblastoma (GBM) is an aggressive malignant brain tumor with 2 year survival rates of 6.7% (Stupp et al. in J Clin Oncol Off J Am Soc Clin...
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Contact Guidance Drives Upward Cellular Migration at the Mesoscopic Scale
IntroductionCancer metastasis is associated with increased cancer incidence, recurrence, and mortality. The role of cell contact guidance behaviors...
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Fabrication of 3D-printed molds for polydimethylsiloxane-based microfluidic devices using a liquid crystal display-based vat photopolymerization process: printing quality, drug response and 3D invasion cell culture assays
Microfluidic platforms enable more precise control of biological stimuli and environment dimensionality than conventional macroscale cell-based...
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Modeling force application configurations and morphologies required for cancer cell invasion
We show that cell-applied, normal mechanical stresses are required for cells to penetrate into soft substrates, matching experimental observations in...
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Adipocytokine Vaspin Stimulates the Migration Process in Different Colorectal Cancer Cell Lines
Colorectal carcinoma cell lines differ in invasiveness and migratory potential. Cell motility characterizes the tissue and specific resistance to...
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Trisomy 21 Alters Cell Proliferation and Migration of iPSC-Derived Cardiomyocytes on Type VI Collagen
PurposeIndividuals with Down syndrome (DS) are 2000 times more likely to develop a congenital heart defect (CHD) than the typical population Freeman...
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Role of Computational Fluid Dynamics in Cancer
Millions of people die from cancer every year, and despite considerable medical advancements, there are still a lot of challenges that need to be...
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Benzofuran Substituted Chalcone Derivatives Trigger Apoptotic Cell Death Through Extrinsic Pathway in Human Lung and Breast Cancer Cells
In this study, the anticancer potential of benzofuran-substituted chalcone derivatives Compound 1 [(3-(Benzofuran-2-yl) -5-(4-N,...
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MicroRNAs in Cancer
The dysrégulation of microRNAs in cancer was first reported in 2002, when a cluster of two microRNAs (miR16 and miR-15) was detected at chromosome...
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Novel Silymarin-Loaded Biosynthesized AgNPs for Improving Anticancer Activities in Breast Cancer
Plant-derived compounds with anti-cancer effects are known as new candidates for treatment. Silymarin is one of these effective compounds; however,...
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The significance of homeodomain transcription factor 2 in colon cancer cells
BackgroundColon cancer is a serious malignant tumor. It has been reported that paired-like homeodomain transcription factor 2 (PITX2) can promote the...
