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P-Cadherin and WNT5A expression in assessment of lymph node metastasis in oral squamous cell carcinoma
BackgroundOral cancer progression is a multi-step process in which adhesion molecules play a pivotal role in the development of recurrent, invasive,...
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PRX1-positive mesenchymal stem cells drive molar morphogenesis
Mammalian teeth, develo** inseparable from epithelial-mesenchymal interaction, come in many shapes and the key factors governing tooth morphology...
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Wnt pathway inhibitors are upregulated in XLH dental pulp cells in response to odontogenic differentiation
X-linked hypophosphatemia (XLH) represents the most common form of familial hypophosphatemia. Although significant advances have been made in the...
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Temporal gene expression profiling during early-stage traumatic temporomandibular joint bony ankylosis in a sheep model
BackgroundInvestigating the molecular biology underpinning the early-stage of traumatic temporomandibular joint (TMJ) ankylosis is crucial for...
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Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1
Bone regeneration remains a great clinical challenge. Low intensity near-infrared (NIR) light showed strong potential to promote tissue regeneration,...
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KAT2A-mediated succinylation modification of notch1 promotes the proliferation and differentiation of dental pulp stem cells by activating notch pathway
BackgroundDental pulp stem cells (DPSCs) are a kind of undifferentiated dental mesenchymal stem cells with strong self-renewal ability and...
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Biological Events at the Interface Between the Radicular Part of a Dental Implant and Bone
The integration of the endosseous portion of a dental implant relies heavily on interactions in the implant microenvironment. A complex biological...
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Exploring the Role of Wnt Ligands in Osteogenic Differentiation of Human Periodontal Ligament Stem Cells
ObjectivesThis study aimed to investigate the functions of 19 types of Wnt ligands during the process of osteogenic differentiation in human...
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Signaling pathways of dental implants’ osseointegration: a narrative review on two of the most relevant; NF-κB and Wnt pathways
IntroductionCell signaling pathways are the biological reactions that control cell functions and fate. They also directly affect the body reactions...
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Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny
Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation. The initiation of Hertwig’s epithelial root...
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Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis: therapeutic potential for endogenous pulp regeneration
Pulp loss is accompanied by the functional impairment of defense, sensory, and nutrition supply. The approach based on endogenous stem cells is a...
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Wnt signaling in periodontitis
ObjectiveThis study aimed to evaluate the Wnt/β-catenin signaling pathway activity in gingival samples obtained from patients with periodontitis.
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Dental stem cell-derived extracellular vesicles as promising therapeutic agents in the treatment of diseases
Dental stem cells (DSCs), an important source of mesenchymal stem cells (MSCs), can be easily obtained by minimally invasive procedures and have been...
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Mesenchymal stem cell-derived extracellular vesicles for treatment of bone loss within periodontitis in pre-clinical animal models: a meta-analysis
BackgroundMesenchymal stem cell-derived extracellular vesicles (MSC-EVs) represent an effective and promising strategy for periodontitis, although...
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CTHRC1 is a prognostic biomarker correlated with immune infiltration in head and neck squamous cell carcinoma
BackgroundHead and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, characterized by high morbidity, high...
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Inhibition of ZDHHC16 promoted osteogenic differentiation and reduced ferroptosis of dental pulp stem cells by CREB
BackgroundThe repair of bone defects caused by periodontal diseases is a difficult challenge in clinical treatment. Dental pulp stem cells (DPSCs)...
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Assessment of risk factors and molecular biomarkers in children with supernumerary teeth: a single-center study
BackgroundSupernumerary teeth are considered one of the commonly observed dental anomalies in children. Several theories have been proposed to...
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FACEts of mechanical regulation in the morphogenesis of craniofacial structures
During embryonic development, organs undergo distinct and programmed morphological changes as they develop into their functional forms. While...
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Oral microbiome contributes to the failure of orthodontic temporary anchorage devices (TADs)
BackgroundThe stability of temporary anchorage devices (TADs) is critical in orthodontic clinics. The failure of TADs is multifactorial, and the role...
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Comprehensive analysis of DNA methylation for periodontitis
BackgroundPeriodontitis is an infectious disease, and a risk factor for peri-implantitis that could result in the implant loss. DNA methylation has...
