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3D finite-element brain modeling of lateral ventricular wall loading to rationalize periventricular white matter hyperintensity locations
Aging-related periventricular white matter hyperintensities (pvWMHs) are a common observation in medical images of the aging brain. The underlying...
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A High-Fidelity 3D Micromechanical Model of Ventricular Myocardium
Pulmonary arterial hypertension (PAH) imposes a pressure overload on the right ventricle (RV), leading to myofiber hypertrophy and remodeling of the...
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Pump and Tissue Function in the Infarcted Heart Supported by a Regenerative Assist Device: A Computational Study
Adverse ventricular remodelling following acute myocardial infarction (MI) may induce ventricular dilation, fibrosis and loss of global contractile...
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A Micro-anatomical Model of the Infarcted Left Ventricle Border Zone to Study the Influence of Collagen Undulation
Myocardial infarction (MI) results in cardiac myocyte death and often initiates the formation of a fibrotic scar in the myocardium surrounded by a...
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Assessment of the Evolution of Temporal Segmental Strain in a Longitudinal Study of Myocardial Infarction
In this study, we propose an approach for the assessment of the evolution of heart function in a population of ST-elevation myocardial infarction...
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A Framework for Evaluating Myocardial Stiffness Using 3D-Printed Heart Phantoms
MRI-driven computational modeling is increasingly used to simulate in vivo cardiac mechanical behavior and estimate subject-specific myocardial...
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An Exploratory Assessment of Focused Septal Growth in Hypertrophic Cardiomyopathy
Growth and Remodelling (G&R) processes are typical responses to changes in the heart’s loading conditions. The most frequent types of growth in the...
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Big Data in multiscale modelling: from medical image processing to personalized models
The healthcare industry is different from other industries–patient data are sensitive, their storage needs to be handled with care and in compliance...
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A Simple Multi-scale Model to Evaluate Left Ventricular Growth Laws
Cardiac growth is the natural capability of the heart of adapting to changes in blood flow demands. Cardiac diseases can trigger the same process...
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Sensitivity of Myocardial Stiffness Estimates to Inter-observer Variability in LV Geometric Modelling
Heart failure is known to be associated with substantial changes in the mechanical properties of the heart muscle. Biomechanical parameters, such as...
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Modeling Cardiac Growth: An Alternative Approach
Models of cardiac growth might assist in clinical decision making, in particular for long-term prognosis of the effect of interventions. Most growth...
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Minimally-Invasive Estimation of Patient-Specific End-Systolic Elastance Using a Biomechanical Heart Model
The end-systolic elastance ( \(E_{\text {es}}\)...
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Heart sound signal recovery based on time series signal prediction using a recurrent neural network in the long short-term memory model
In this research, we propose a method for recovering heart sound signals that comprises the long short-term memory prediction model based on the...
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A Comprehensive Comparison of GPU Implementations of Cardiac Electrophysiology Models
Cardiac disease is the leading cause of death in developed countries, and arrhythmias, which are disorders in the regular generation and propagation...
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A Multiple Kernel Learning Framework to Investigate the Relationship Between Ventricular Fibrillation and First Myocardial Infarction
Myocardial infarction results in changes in the structure and tissue deformation of the ventricles. In some cases, the development of the disease may...
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Improving Understanding of Long-Term Cardiac Functional Remodelling via Cross-Sectional Analysis of Polyaffine Motion Parameters
Changes in cardiac motion dynamics occur as a direct result of alterations in structure, hemodynamics, and electrical activation. Abnormal...
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Electrical and Physical Sensors for Biomedical Implants
In addition to the electrochemical sensors discussed in Chap. 2 , a range of other sensing modalities are...
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Classification of Myocardial Infarcted Patients by Combining Shape and Motion Features
Myocardial infarction changes both the shape and motion of the heart. In this work, cardiac shape and motion features are extracted from shape models...
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Left Ventricular Diastolic and Systolic Material Property Estimation from Image Data
Cardiovascular simulations using patient-specific geometries can help researchers understand the mechanical behavior of the heart under different...
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Feasibility of the Estimation of Myocardial Stiffness with Reduced 2D Deformation Data
Myocardial stiffness is a useful diagnostic and prognostic biomarker, but only accessible through indirect surrogates. Computational 3D cardiac...