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Determination of Umifenovir and Its Metabolites by High-Performance Liquid Chromatography with Combined Mass Spectrometric Detection
AbstractAn approach to the highly sensitive and selective determination of the bromine-containing antiviral drug umifenovir (Arbidol) and its...
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An autonomous portable platform for universal chemical synthesis
Robotic systems for synthetic chemistry are becoming more common, but they are expensive, fixed to a narrow set of reactions, and must be used within...
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Transformation of Organic Compounds during Water Chlorination/Bromination: Formation Pathways for Disinfection By-Products (A Review)
AbstractThe purity of drinking water is an important issue of the human life quality. Water disinfection has saved millions people from the diseases...
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Nano-Drug Delivery Systems for COVID-19 Drug Delivery
Currently, SARS-CoV-2 (COVID-19) is the dominant disease in the globe. It has resulted into major economic disruption and social disturbance all...
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Computational insight of repurpose drug for treatment of COVID-19: a CDFT approach
The COVID-19 is recognized as one of the deadly disease in the history of human life. It is caused by the severe acute respiratory syndrome...
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Current Strategies to Combat COVID-19
The outbreak of the novel coronavirus disease (COVID-19) has created global crisis. It originated from Wuhan, China, and has outspread globally. The...
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A one-pot thiomethylation of pyrrole and indoles
C(sp 2 )H functionalization of pyrrole, indole, indolyl-3-acetic acid (heteroauxin), and 2-amino-3-(indol-3yl)propionic acid (tryptophan) was carried...
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Coumarins as Emerging Anti-Viral Compounds from Natural Origins: Ethnopharmacology, Chemistry, Mechanism of Action, Clinical and Preclinical Studies, and Future Perspectives
From the natural origin, more than 1300 coumarins have already been recognized. Coumarins are natural products and secondary metabolites in plants,...
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A Chromatography–Mass Spectrometry Study of the Transformation of the Benzalkonium Cation in Aqueous Solutions under the Action of Active Bromine
AbstractBenzalkonium salts are widely used in the composition of antimicrobial preparations in industry and everyday life and as algaecides to treat...
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Coumarins as Emerging Antiviral Compounds from Natural Origins: Ethnopharmacology, Chemistry, Mechanism of Action, Clinical, Preclinical Studies, and Future Perspectives
From the natural origin, more than 1300 coumarins have already been recognized. Coumarins are natural products and secondary metabolites in plants,...
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Identification of multi-targeting natural antiviral peptides to impede SARS-CoV-2 infection
SARS-CoV-2 and its variants cause serious health concerns throughout the world. The alarming increase in the daily number of cases has become a...
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In Silico Evaluation of Prospective Anti-COVID-19 Drug Candidates as Potential SARS-CoV-2 Main Protease Inhibitors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emanating human infectious coronavirus that causes COVID-19 disease. On...
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Bioactive Compounds and Biological Activities of Allium sativum L.
The therapeutic properties of the dynamically bioactive components found in garlic (Allium sativum L.), including allicin, alliin,...
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Phytomolecules and Novel Drug Delivery Approach for COVID-19
Coronavirus disease 2019 (COVID-19) has been a recent pandemic where very rarely few therapeutic modalities are effective in the treatment and...
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COVID-19: Molecular Pathogenesis and Prospective Therapeutic Interventions
COVID-19 is a catastrophe taking a massive toll on humanity across the world. It is a highly transmissible airborne infection. The pathogen...
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Bioactive Compounds and Biological Activities of Allium sativum L.
The therapeutic properties of the dynamically bioactive components found in garlic (Allium sativum L.), including allicin, alliin,...
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The evolution of the global COVID-19 epidemic in Morocco and understanding the different therapeutic approaches of chitosan in the control of the pandemic
In 2020, Coronavirus disease (COVID-19), a new viral respiratory disease caused by a virus that belongs to Coronaviridae family, has been identified....
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Main Chemotypes of SARS-CoV-2 Reproduction Inhibitors
AbstractThe COVID-19 pandemic has forced scientists all over the world to focus their effort on searching for targeted drugs for coronavirus...
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α-Substituted β-mercapto ketone based synthesis of 3-alkyl-3-[(alkylsulfanyl)methyl]-2-methyl-3H-indoles
A novel approach to the synthesis of 3-(alkylsulfanylmethyl)-substituted 1 H -indoles was developed based on the Fischer indole synthesis involving...
