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1. Prodrugs

   Prodrugs are a widely deployed strategy for medical chemists. Introduction of the prodrug typically moderates the physicochemical properties of the...

   Adrian Hobson in The Medicinal Chemistry of Glucocorticoid Receptor Modulators

   Chapter 2023
   

2. Synthesis, characterization and pharmacological screening of etodolac amino acid’s mutual prodrugs

   Etodolac is the drug of choice for pain and inflammation associated with rheumatoid arthritis. Here, the mutual prodrugs of etodolac were synthesized...

   Gaurav Krishna, Kamal Shah in Chemical Papers

   Article 21 February 2024
   

3. Synthesis of Pregnane–Cholesterol and Cholesterol–Cholesterol Prodrugs via Ring A–Ring A Connection. Potential Cytotoxic Activity against Cervical Cancer Cell Line HeLa

   Abstract

   Two novel pregnane–cholesterol and cholesterol–cholesterol prodrugs have been synthesized. The synthetic route involved preparation of...

   P. Yadav, N. Yadav, ... S. Srivastava in Russian Journal of Organic Chemistry

   Article 01 October 2023
   

4. Pt(IV) Complexes in the Search for Novel Platinum Prodrugs with Promising Activity

   The kinetically inert, six coordinated, octahedral Pt(IV) complexes are termed dual-, triple-, or multi-action prodrugs based on the nature of the...

   Sainath Aher, **hua Zhu, ... **uhua Liu in Topics in Current Chemistry

   Article 24 February 2024
   

5. Dual Diomarkers Triggered Prodrugs for Precise Treatment of Melanoma: Design, Synthesis and Activities

   Targeted prodrug strategy, which utilizes the endogenous biomarkers in cancer cells as activators to release the active drug, has been well...

   Yawen Ruan, Peiling Huang, ... **g Huang in Chemical Research in Chinese Universities

   Article 14 June 2022
   

6. Radiotherapy activates picolinium prodrugs in tumours

   Radiotherapy-induced prodrug activation provides an ideal solution to reduce the systemic toxicity of chemotherapy in cancer therapy, but the scope...

   Qunfeng Fu, Zhi Gu, ... Zhibo Liu in Nature Chemistry

   Article 01 April 2024
   

7. Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery

   A widely established prodrug strategy can effectively optimize the unappealing properties of therapeutic agents in cancer treatment. Among them,...

   Lingling Huang, Jianmiao Yang, ... Donghang Xu in Journal of Nanobiotechnology

   Article Open access 24 January 2022
   

8. First- and Second-Generation Nucleoside Triphosphate Prodrugs: TriPPPro-Compounds for Antiviral Chemotherapy

   Currently, a number of biologically active nucleoside analogues are extensively used as antiviral, anticancer, antiparasitic, and antibacterial...

   **ao Jia, Chenglong Zhao, Chris Meier in Handbook of Chemical Biology of Nucleic Acids

   Reference work entry 2023
   

9. Switching on prodrugs using radiotherapy

   Chemotherapy is a powerful tool in the armoury against cancer, but it is fraught with problems due to its global systemic toxicity. Here we report...

   ** Geng, Yichuan Zhang, ... Mark Bradley in Nature Chemistry

   Article 10 June 2021
   

10. First and Second Generation Nucleoside Triphosphate Prodrugs: TriPPPro-Compounds for Antiviral Chemotherapy

    Currently, a number of biologically active nucleoside analogues are extensively used as antiviral, anticancer, antiparasitic, and antibacterial...

    **ao Jia, Chenglong Zhao, Chris Meier in Handbook of Chemical Biology of Nucleic Acids

    Living reference work entry 2022
    

11. Design Principles and Development of Prodrugs for Multiply Active Antibacterials

    Added layers of complexity in design are inherent with multi-action agents released from prodrugs, and though challenging, such prodrugs do offer...

    John Bremner in Multiple Action-Based Design Approaches to Antibacterials

    Chapter 2021
    

12. New acetylenic derivatives of bile acids as versatile precursors for the preparation of prodrugs. Synthesis and cytotoxicity study

    Three groups of bile acid derivatives with acetylenic moieties, such as propargyl, hex-5-ynoyl, and 4,7,10,13-tetraoxahexadec-15-ynoyl ones, were...

    Yu. R. Pavley, E. Yu. Yamansarov, ... E. K. Beloglazkina in Russian Chemical Bulletin

    Article 01 March 2023

13. Synthesis of diosgenin prodrugs: anti-inflammatory and antiproliferative activity evaluation

    Abstract

    In this work, we evaluated the antiproliferative and anti-inflammatory activities of two diosgenin prodrugs. The prodrugs were obtained by...

    Leydi M Carrillo-Cocom, Bethsabe B Villagómez González, ... Jacqueline Capataz Tafur in Journal of Chemical Sciences

    Article 11 August 2020
    

14. Domino Dendrimers

    Domino dendrimers have recently been developed and introduced as a potential platform for a single triggered multi-prodrug. Surprisingly, three...

    Roey J. Amir, Doron Shabat in Polymer Therapeutics I

    Chapter
    

15. Hydrogen-bonded organic framework-based bioorthogonal catalysis prevents drug metabolic inactivation

    Bioorthogonal chemistry provides a new avenue for disease treatment by generating therapeutic agents in situ. However, two crucial issues have to be...

    Congcong Huang, Chuanqi Zhao, ... **aogang Qu in Nature Catalysis

    Article 10 August 2023
    

16. DSC studies on the interaction of lipophilic cytarabine prodrugs with DMPC multilamellar vesicles

    Cytarabine (1-β- d -arabinofuranosylcytosine, Ara-C), a pyrimidine nucleoside analogue, is used for the treatment of both acute and chronic...

    Jhon Fernando Berrio Escobar, Diana Margarita Marquez Fernandez, ... Maria Grazia Sarpietro in Journal of Thermal Analysis and Calorimetry

    Article 12 September 2019
    

17. Correction: Cyclopeptidic photosensitizer prodrugs as proteolytically triggered drug delivery systems of pheophorbide A: part I – self-quenched prodrugs

    The authors regret a spelling mistake in the surname of one of the authors. The surname given as Yuschenko should be Yushchenko. The correct spelling...

    Jordan Bouilloux, Oleksandr Yushchenko, ... Norbert Lange in Photochemical & Photobiological Sciences

    Article Open access 01 November 2019

18. A3 Adenosine Receptor Ligands: From Discovery to Clinical Trials

    Numerous classes of selective agonists, antagonists, and allosteric modulators of the A3 adenosine receptor (AR) have been reported. The...

    Kenneth A. Jacobson, Paola Oliva, R. Rama Suresh in Purinergic Receptors and their Modulators

    Chapter 2023
    

19. Cross-linked lipoic acid nanocapsules serve as H₂O₂ amplifier to strengthen the H₂O₂-sensitive prodrug activation

    The H ₂ O ₂ -triggered prodrug activation represents a hot topic while the low H ₂ O ₂ level of cancer cells hindered the complete activation of parent...

    Jiangbing Tan, Pei **g, ... Shiyong Zhang in Science China Chemistry

    Article 31 July 2023
    

20. Amino acid tethered benzoxazolone as highly potent inhibitors of O-glycosylation

    Novel inhibitors of GlcNAc-Ts have been reported based on benzoxazolone appended amino acids/esters which showed a competitive inhibition of the...

    Tanisqa Mall, Mousmee Sharma, Parteek Prasher in Chemical Papers

    Article 24 April 2024