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Quantitative biochemical phenotypic heterogeneity of senescent macrophage at a single cell level by Synchrotron Radiation Fourier Transform Infrared Microspectroscopy
Macrophage senescence plays an important role in pathophysiological process of age-related diseases such as atherosclerosis, chronic obstructive...
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Macrophage-Targeted Nanomedicines
Macrophages are versatile cells of the innate immune system responsible for the control and progressions of a variety of autoimmune inflammatory,...
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Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment
Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted therapy, but their simple biological functionalization is...
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M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposus cell senescence through LCN2/NF-κB signaling axis
Intervertebral disc degeneration (IVDD) is the primary factor contributing to low back pain (LBP). Unlike elderly patients, many young IVDD patients...
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M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived...
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Fish cell line: depositories, web resources and future applications
Cell lines are important bioresources to study the key biological processes in the areas like virology, pathology, immunology, toxicology,...
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Development of finely tuned liposome nanoplatform for macrophage depletion
BackgroundImmunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously...
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Nanotube patterning reduces macrophage inflammatory response via nuclear mechanotransduction
The inflammatory immune environment surrounding titanium bone implants determines the formation of osseointegration, and nanopatterning on implant...
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The Therapeutic Potential of 4-Methoxy-1-methyl-2-oxopyridine-3-carbamide (MMOXC) Derived from Ricinine on Macrophage Cell Lines Infected with Methicillin-Resistant Strains of Staphylococcus aureus
The incidences of methicillin-resistant strains of Staphylococcus aureus (MRSA) and their survival inside the macrophages are the major attributes of...
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Immunostimulatory potential of extruded plant-based meat: effect of extrusion moisture level on macrophage activation
In this study, the effect of different moisture levels in extruded plant-based meat on macrophage immunostimulation, and the potential of this meat...
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Macrophage membrane-derived pH-responsive nanovesicles to target tumor cells with integrin α4β1 receptor
In this study, we developed macrophage-derived nanovesicles (MNVs) to specifically target tumor cells. Initially, we chemically coupled hyaluronic...
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Calcium phosphate coating enhances osteointegration of melt electrowritten scaffold by regulating macrophage polarization
The osteoimmune microenvironment induced by implants plays a significant role in bone regeneration. It is essential to efficiently and timely switch...
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Label-Free and Real-Time Electrical Impedance Monitoring of Macrophage Polarization of THP-1 Monocytes on Indium Tin Oxide Electrode
Macrophages are immune cells that play important roles in the human body’s initial immune responses against pathogens and tumor cells. We...
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Construction and Evaluation of an M2 Macrophage-Related Prognostic Model for Colon Cancer
Colon cancer (CC) is a primary human malignancy. Recently, the mechanism of the tumor microenvironment (TME) in CC has been a hot topic of research....
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A novel extracellular vesicles production system harnessing matrix homeostasis and macrophage reprogramming mitigates osteoarthritis
Osteoarthritis (OA) is a degenerative disease that significantly impairs quality of life. There is a pressing need for innovative OA therapies. While...
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A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy
Periodontitis is a chronic inflammation caused by a bacterial infection and is intimately associated with an overactive immune response. Biomaterials...
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Baicalin nanodelivery system based on functionalized metal-organic framework for targeted therapy of osteoarthritis by modulating macrophage polarization
Intra-articular drugs used to treat osteoarthritis (OA) often suffer from poor pharmacokinetics and stability. Nano-platforms as drug delivery...
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Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury
Patients who suffer from sepsis typically experience acute lung injury (ALI). Extracellular vesicles (EVs) contain miRNAs, which are potentially...
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Phytol from Scoparia dulcis prevents NF-κB-mediated inflammatory responses during macrophage polarization
Macrophages are primary immune cells that mediate a wide range of inflammatory diseases through their polarization potential. In this study, phytol...
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Targeting and repolarizing M2-like tumor-associated macrophage-mediated MR imaging and tumor immunotherapy by biomimetic nanoparticles
Anti-tumor M1-like and pro-tumor M2-like tumor-associated macrophages (TAMs) coexist in tumor microenvironments (TME). The adverse effects of these...
