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Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates (K-BIPS)
Phosphorylation is a reversible post-translational modification that alters the functions of proteins to govern various cellular events, including...
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Programmed RNA editing with an evolved bacterial adenosine deaminase
Programmed RNA editing presents an attractive therapeutic strategy for genetic disease. In this study, we developed bacterial deaminase-enabled...
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In Silico Insights Toward the Exploration of Adenosine Receptors Ligand Recognition
Adenosine receptors have been studied for many years now, their structures have been resolved and many of the determinants for their interaction...
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Adenosine A2A Receptor Antagonists: Chemistry, SARs, and Therapeutic Potential
Many physiological processes are modulated by the naturally occurred nucleoside adenosine after interaction with four G-protein-coupled receptor...
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In vitro biosynthesis of ATP from adenosine and polyphosphate
Adenosine triphosphate (ATP) acts as a crucial energy currency in vivo , and it is a widely used energy and/or phosphate donor for enzyme-catalyzed...
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Allosteric Modulators of Adenosine Receptors
Allosterism occurs when a ligand binds to a receptor on a binding site distinct from the orthosteric one to which endogenous ligand normally binds....
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Sodium-potassium Adenosine Triphosphatase α2 Subunit (ATP1A2) Negatively Regulates UCP1-dependent and UCP1-independent Thermogenesis in 3T3-L1 Adipocytes
Increasing the number of brite cells (browning) in white adipocytes has attracted considerable attention to combat obesity because brite cells also...
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Preparation of 5-[131I]iodotubercidin for the detection of adenosine kinase
5-Iodotubercidin is a prototype adenosine kinase (AK) inhibitor with potent anti-seizure activity in rodent epilepsy models. Using the chloramine-T...
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Once Upon a Time Adenosine and Its Receptors: Historical Survey and Perspectives as Potential Targets for Therapy in Human Diseases
Endogenous autacoid adenosine plays important physiological roles in various tissues and organs by acting through A1, A2A, A2B, and A3 receptors....
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Plasmodium falciparum FIKK 9.1 kinase modeling to screen and identify potent antimalarial agents from chemical library
The Plasmodium FIKK kinases are diverged from human kinases structurally. They harbour conserved ATP-binding domains that are non-homologous to other...
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Specific unlocking of the butterfly effect: nanointerface-based electrochemical biosensing of adenosine triphosphate and alkaline phosphatase
The purpose of this study was to achieve a specific unlocking of the butterfly effect: nanointerface-based electrochemical biosensing of adenosine...
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Development of selective inhibitors of phosphatidylinositol 3-kinase C2α
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial...
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Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress
ContextCalcium-dependent signaling in plants is responsible for several major cellular events, including the activation of the salinity-responsive...
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Unveiling Potential Targeted Therapeutic Opportunities for Co-Overexpressed Targeting Protein for Xklp2 and Aurora-A Kinase in Lung Adenocarcinoma
Lung adenocarcinoma (LUAD) is one of the most prevalent and leading causes of cancer deaths globally, with limited diagnostic and clinically...
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A2B Adenosine Receptor as a New and Attractive Target to Treat Brain Ischemia or Demyelination
Ischemic stroke is one of the most prevalent vascular diseases worldwide that cause a decline in quality of life and a high mortality rate. Cerebral...
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An electrochemical biosensor for T4 polynucleotide kinase activity identification according to host–guest recognition among phosphate pillar[5]arene@palladium nanoparticles@reduced graphene oxide nanocomposite and toluidine blue
T4 polynucleotide kinase (T4 PNK) helps with DNA recombination and repair. In this work, a phosphate pillar[5]arene@palladium nanoparticles@reduced...
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Resveratrol butyrate esters inhibit lipid biosynthesis in 3T3-L1 cells by AMP-activated protein kinase phosphorylation
Resveratrol butyrate esters (RBEs), which are novel resveratrol-synthesized derivatives, exhibit increased biological activity. This study elucidated...
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A computational study to reveal selpercatinib resistance to RET kinase double mutant V804M/Y806C
As a member of the receptor tyrosine kinase family, rearranged during transfection (RET) kinase has received increased interest as a therapeutic...
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Bifunctional Tools to Study Adenosine Receptors
Target-based G protein-coupled receptors (GPCRs) drug discovery has historically focused on the development of ligands that either activate or...
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Kinase expression enhances phenolic aldehydes conversion and ethanol fermentability of Zymomonas mobilis
Kinases modulate the various physiological activities of microbial fermenting strains including the conversion of lignocellulose-derived phenolic...
