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Future perspective: high-throughput construction of new ultrasensitive cytokine and virion liquid chips for high-throughput screening (HTS) of anti-inflammatory drugs or clinical diagnosis and treatment of inflammatory diseases
Pathogen–host cell interactions play an important role in many human infectious and inflammatory diseases. Several pathogens, including Escherichia...
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Encoding Noncanonical Amino Acids into Phage Displayed Proteins
Phage display facilitates the evolution of peptides and proteins for affinity selection against targets, but it is mostly limited to the chemical...
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Kennedy Epitope (KE)-dependent Retrograde Transport of Efficiently Cleaved HIV-1 Envelopes (Envs) and its Effect on Env Cell Surface Expression and Viral Particle Formation
Efficiently cleaved HIV-1 Envs are the closest mimics of functional Envs as they specifically expose only bNAb (broadly neutralizing antibody)...
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Poxvirus and the Role of Medicinal Plants in Controlling Infections: Ethnopharmacology, Chemistry, Clinical and Preclinical Studies, and Future Perspectives
Today, viral infections are causing an unexpectedly high incidence of mortality over the world. The enormous double-stranded DNA genomes of...
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Construction and characterization of a novel miniaturized filamentous phagemid for targeted mammalian gene transfer
BackgroundAs simplistic proteinaceous carriers of genetic material, phages offer great potential as targeted vectors for mammalian transgene...
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Lipid-Mediated Effect of Glycyrrhizin on the Properties of the Transmembrane Domain of the E-Protein of the Sars-Cov-2 Virus
AbstractThe interaction of glycyrrhizin with the transmembrane domain of the E-protein of the SARS-CoV-2 virus (E-protein Trans-Membrane domain, ETM)...
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Drug Resistance in Antiviral Therapy
Drug resistance in antiviral therapy is a major public health challenge. This resistance can occur among immunocompromised patients where persistent...
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Poxvirus and the Role of Medicinal Plants in Controlling Infections: Ethnopharmacology, Chemistry, Clinical, Preclinical Studies, and Future Perspectives
Today, viral infections are causing an unexpectedly high incidence of mortality over the world. The enormous double-stranded DNA genomes of...
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Computational Modeling in the Development of Antiviral Agents
As a result of the damage that viruses have done over time, humans have developed a variety of defenses against viral illnesses, such as vaccines and...
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Delivery of Fc-fusion Protein by a Recombinant Newcastle Disease Virus Vector
Fc-fusion proteins (FCPs), a new generation biological medicine, have revolutionized the practice of medicines that treat diseases. However, complex...
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Recent Developments in the Treatment of Influenza
Influenza infections are associated with elevated levels of mortality and morbidity in young children, the elderly, and the immunocompromised....
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Negative-Strand RNA Virus-Vectored Vaccines
Vectored RNA vaccines offer a variety of possibilities to engineer targeted vaccines. They are cost-effective and safe, but replication competent,...
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M13 Bacteriophage-Based Bio-nano Systems for Bioapplication
M13 bacteriophage is a promising biomolecule with unique biochemical and structural traits (e.g., high aspect ratio, 2700 copies of identical coat...
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
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Drug Delivery Options for Treatment of Ebola Infection
In West Africa, the Ebola virus disease (EVD) outbreak between 2013 and 2016 is considered as one of the deadliest re-emerging viruses, which began...
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Tobacco-Based Vaccines, Hopes, and Concerns: A Systematic Review
Emerging infectious diseases have vigorously devastated the global economy and health sector; cost-effective plant-based vaccines (PBV) can be the...
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Proteome-Based Investigation Identified Potential Drug Repurposable Small Molecules Against Monkeypox Disease
Monkeypox Virus (MPXV), the causative agent of Monkeypox (MPX) disease, is an emerging zoonotic pathogen spreading in different endemic and...
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Production of Oral Vaccines Based on Virus-Like Particles Pseudotyped with Protozoan-Surface Proteins
Giardia lamblia is the only known parasite that can inhabit the harsh upper gastrointestinal tract, where most of the digestive proteases are...
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Ligand Selection for Affinity Chromatography Using Phage Display
Phage display coupled with in vitro affinity selection to mimic evolutionary principles has propelled the discovery of specific binding peptides and...
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Promising Functional Supramolecules in Antiviral Drugs
Viral infections have imposed several global health challenges, owing to the emergence of resistant viral strains and the subsequent adverse effects...