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UHPLC- and MS/MS-Mediated Analysis and Quantification of Postbiotic Cobalamin (Vitamin B12) from Propionibacterium freudenreichii
Vitamin B12 is one of the major nutritional sources that is involved in the functions such as cell regeneration and nerve functioning. People with...
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UHPLC-MS/MS Approach for Following Nimodipine Saturation Kinetics in Acute Rat Brain Slice
Nimodipine (NMD) has gained increasing attention in the latest scientific studies as it can act alone or in combination with other drugs to relieve...
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Development, Optimization, and Validation of a Sensitive UHPLC-MS/MS Method for the Determination of Hainanmycin in Chicken Meat and Eggs
This work presented an analytical method to determine hainanmycin in chicken meat and eggs using ultra high-performance liquid chromatography-tandem...
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A UHPLC-MS/MS Method for the Quantification of Wheat Gluten in Commercial Food Products Using Summarized Marker Peptide Contents
Gluten proteins may cause adverse reactions when consumed by predisposed individuals. In dietary gluten-free products, its content must not exceed...
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Simultaneous determination of seven bile acids to study the effect of ivermectin on their plasma levels in rat by UHPLC–MS/MS
Bile acids (BAs) are considered to be important diagnostic biomarkers to understand the pathophysiology of hepatobiliary and metabolic diseases. BAs...
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A novel reagent pre-column derivatization method for UHPLC-MS/MS to determine four α-dicarbonyl compounds in beer
The detection and analysis of α-dicarbonyl compounds (α-DCs) in food can guide the daily diet of patients with various chronic diseases. However,...
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Overview of UHPLC-MS: an Effective and Sensitive Hyphenated Technique
AbstractThis review describes the importance of UHPLC-MS in different fields and highlights the advancement in this hyphenated technique. The...
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TiO2@COF-based solid-phase microextraction combined with UHPLC-MS/MS for the rapid determination of potential biomarkers of phosphatidylcholines and lysophosphatidylcholines in head and neck cancers
Phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), two types of phospholipids (PLs), have been reported to be closely correlated with head...
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Multiple Response Optimization of an Ionic Liquid-DLLME and UHPLC-DAD Analysis of Five Coccidiostats in the Chicken Liver with LC–MS/MS Confirmation
Pharmaceutical residues in animal food products from various sources are a crucial concern regarding food safety measures for human welfare....
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Multiresidue Determination of Pesticides in Potato Tuber, Peel, and Pulp by QuEChERS and UHPLC-MS/MS
Pesticides have been widely used to control pests and weeds during food production or storage, but when used incorrectly, they can cause damage to...
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Comprehensive characterization of Epimedium-Rhizoma drynariae herb pair in rat plasma, urine, and feces metabolic profiles by UHPLC-Q-Orbitrap HRMS combined with diagnostic extraction strategy and multicomponent pharmacokinetic study by UHPLC-MS/MS
Epimedium-Rhizoma drynariae (EP-RD) was a well-known herb commonly used to treat bone diseases in traditional Chinese medicine. Nevertheless, there...
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UHPLC‐Q‐TOF‐MS/MS‐guided dereplication to study chemical constituents of Hedera nepalensis leaves in northern Vietnam
Hedera nepalensis is commonly used as a traditional medicine for the treatment of several diseases . In this research, the efficient characterization...
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A novel UHPLC‒MS/MS method for quantitative analysis of zanubrutinib in rat plasma: application to an in vivo interaction study between zanubrutinib and triazole antifungal
BackgroundThis study establishes a UHPLC‒MS/MS method for the detection of zanubrutinib and explores its interaction with fluconazole and...
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Identification and Semi-quantification of 36 Compounds from Violae herba (Zihuadiding) via UHPLC-Q-Orbitrap-MS/MS as Well as Proposal of Anti-counterfeiting Quality-Marker for Pharmacopeia
Violae herba (Zihuadiding) is a common Chinese herbal medicine. The current Chinese Pharmacopeia (ChP) defines Viola yedoensis Makino as the sole...
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Simultaneous quantification of five DL-amino acids in beer by UHPLC–MS/MS using a novel chiral mass spectrometry probe
A novel UHPLC–MS/MS method with high sensitivity and selectivity for simultaneous detection and chiral resolution of DL-amino acids in beer was...
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Metabolite profiling analysis of plasma, urine, and feces of rats after oral administration of Flos Chrysanthemi Indici preparation through UHPLC-Q-Exactive-MS combined with pharmacokinetic study of markers by UHPLC-QQQ-MS/MS
Zhenju Antihypertensive Tablet is one of the Flos Chrysanthemi Indici preparations (FCIP) with antihypertensive effect. In order to investigate its...
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Separation and Identification of Related Substances in Candesartan Cilexetil Tablets by UHPLC-Q-TOF–MS
Related substances, such as process-related substances and degradation products, may affect the efficacy of drugs and cause adverse reactions....
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A new methodology to reveal potential nucleic acid modifications associated with the risk of endometrial cancer through dispersive solid-phase extraction coupled with UHPLC-QE-Orbitrap-MS/MS and HPLC–UV
Nucleic acid modifications have attracted increasing attention in recent years since they have been found to be related to a number of diseases...
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Determination of Aflatoxins M1, M2, B1, B2, G1, G2 and Ochratoxin A in Infant Formulas from Brazil Using a Modified QuEChERS Method and UHPLC-MS/MS
The aim of this study was to determine the contamination levels by aflatoxins M1, M2, G1, G2, B1 and B2 and Ochratoxin A in 123 infant formula powder...
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Identification of Potential α-Glucosidase Inhibitors from American Ginseng Processed Products by UHPLC-Q-Orbitrap/MS and Molecular Docking
The traditional herb American ginseng ( Panax quinquefolium L.) can be processed into two common products: dried American ginseng (DAG) and red...
