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Naturstoffe als Ausgangsstoffe für die Arzneisynthese
Das Kapitel beleuchtet die wichtige Rolle von Naturstoffen bei der Entwicklung moderner Arzneimittel. Dies wird am Beispiel von Podophyllotoxin,...
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Lipid-Based Drug Delivery for Pneumonia Treatment
Respiratory tract infections are a significant problem that severely impacts public health due to high morbidity and mortality rates. The causes of...
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Targeting undruggable carbohydrate recognition sites through focused fragment library design
Carbohydrate-protein interactions are key for cell-cell and host-pathogen recognition and thus, emerged as viable therapeutic targets. However, their...
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Green Aspects of Flow Chemistry for Drug Discovery
Flow chemistry is considered to be an enabling technology that covers many of the key principles of Green Chemistry. In this chapter, we review the...
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Computational repurposing of drugs for viral diseases and current and future pandemics
A large fraction of the world’s population is directly impacted by acute or chronic viral infections, many of which have high mortality. As was...
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Efficient continuous flow synthesis of ethyl shikimate: the first step in the synthesis of Tamiflu
Ethyl shikimate is the first intermediate in the synthesis of oseltamivir phosphate (Tamiflu). Commercially, it is synthesised from the...
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Porous gold nanoparticles for attenuating infectivity of influenza A virus
BackgroundInfluenza viruses (IVs) have become increasingly resistant to antiviral drugs that target neuraminidase and matrix protein 2 due to gene...
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Extraction and Isolation of Natural Organic Compounds from Plant Leaves Using Ionic Liquids
Plants contain many kinds of natural organic compounds, and their compounds possess many useful properties. Natural organic compounds are important...
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Novel technologies combined with traditional metabolic engineering strategies facilitate the construction of shikimate-producing Escherichia coli
Shikimate is an important intermediate in the aromatic amino acid pathway, which can be used as a promising building block for the synthesis of...
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In silico study of carvone derivatives as potential neuraminidase inhibitors
Recent outbreaks of highly pathogenic influenza strains have highlighted the need to develop new anti-influenza drugs. Here, we report an in silico...
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Chemistry in the Pharmaceutical Industry
This chapter discusses the role of chemistry within the pharmaceutical industry. Although the focus is upon the industry within the United States,...
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Design and synthesis of basic ionic liquids for the esterification of triterpenic acids
AbstractWe present the design and synthesis of Brønsted-basic ionic liquids and investigate their application in the microwave-assisted...
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Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins
The nature of individual sensitivity to drugs associated with molecular polymorphism of human enzymes is discussed. The influence of molecular...
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Process Chemistry in Antiviral Research
This article reviews antiviral therapies that have been approved for human use during the last decade, with a focus on the process chemistry that...
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Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals
This review concerns on recent advances in the application of various modern electrochemical techniques to the analysis of pharmaceuticals and...
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In vitro and in vivo stability of oseltamivir within a bioequivalence trial
A simple, precise, and rapid method to simultaneously determine the levels of oseltamivir (OS) and oseltamivir carboxylate (OSC) in human plasma was...
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Generation of aroE overexpression mutant of Bacillus megaterium for the production of shikimic acid
BackgroundShikimic acid, the sole chemical building block for the antiviral drug oseltamivir (Tamiflu®), is one of the potent pharmaceutical...
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Shikimic Acid Pathway
Of the identified biosynthetic paths, shikimic acid pathway plays a very important role in providing precursors of a large number of aromatic...
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Chiral Alkaline Earth Metal Complexes in Asymmetric Catalysis
Alkaline earth metal catalysis for asymmetric reactions is a hot topic from the viewpoint of green sustainable chemistry. The stable alkaline earth...
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Production of shikimic acid from Escherichia coli through chemically inducible chromosomal evolution and cofactor metabolic engineering
BackgroundShikimic acid (SA) produced from the seeds of Chinese star anise ( Illicium verum ) is a key intermediate for the synthesis of neuraminidase...
