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Integrating CRISPR/Cas12a with strand displacement amplification for the ultrasensitive aptasensing of cadmium(II)
Cadmium ion (Cd(II)) is a pernicious environmental pollutant that has been shown to contaminate agricultural lands, accumulate through the food...
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Photothermal biosensor for HPV16 based on strand-displacement amplification and gold nanoparticles using a thermometer as readout
Gold nanoparticles (AuNPs) in aggregated state have a strong near infrared region (NIR) absorption and the causes a much stronger photothermal effect...
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A target-triggered strand displacement-assisted target recycling based on carbon dots-based fluorescent probe and MSNs@PDA nanoparticles for miRNA amplified detection and fluorescence imaging
A target-triggered strand displacement-assisted target recycling based on carbon dots-based fluorescent probe and mesoporous silica...
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A novel DNA detection using spherical identification probe and strand displacement reaction-initiated silver nanocluster switch
Herein, we developed a novel fluorescent assay using spherical identification probes and toehold-mediated strand displacement reaction-initiated...
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Isothermal circular strand displacement–based assay for microRNA detection in liquid biopsy
Extracellular miRNAs are promising targets for develo** new assays for the early diagnosis and prognosis of diseases based on liquid biopsy. The...
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Simple, sensitive, and label-free miRNA analysis through strand displacement reaction integrating with G-quadruplex-based signal generation
MicroRNAs (miRNAs) play a significant role in the pathogenesis of various diseases throughout biological processes, and the accurate detection of...
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SF-qPCR: Strand Displacement-Based Fast Quantitative Polymerase Chain Reaction
Nucleic acid testing (NAT) is important for the identification and quantification of specific nucleic acid targets, both DNA and RNA, in life...
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Programming cell-free biosensors with DNA strand displacement circuits
Cell-free biosensors are powerful platforms for monitoring human and environmental health. Here, we expand their capabilities by interfacing them...
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Ultrasensitive detection of genetic variation based on dual signal amplification assisted by isothermal amplification and cobalt oxyhydroxide nanosheets/quantum dots
PML/RARα fusion gene (P/R) is the characteristic signature genetic variation of acute promyelocytic leukemia (APL). Here, by integrating...
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Ratiometric electrochemical detection of miRNA based on DNA nanomachines and strand displacement reaction
MicroRNAs (miRNAs) play an important role in regulating gene expression in cells. Abnormal expression of miRNAs has been associated with a variety of...
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A visual denaturation bubble-mediated strand exchange amplification and RGB visual analysis-based assay for quantitative detection of Helicobacter pylori in saliva
Helicobacter pylori ( H. pylori ) is a class I carcinogen causing gastric cancer. Almost 50% of people on earth have been infected and it is worse in...
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PfAgo-based dual signal amplification biosensor for rapid and highly sensitive detection of alkaline phosphatase activity
A Pyrococcus furiosus Argonaute ( Pf Ago)-based biosensor is presented for alkaline phosphatase (ALP) activity detection in which the ALP-catalyzed...
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Three-way junction structure-mediated reverse transcription-free exponential amplification reaction for pathogen RNA detection
Since RNA is an important biomarker of many infectious pathogens, RNA detection of pathogenic organisms is crucial for disease diagnosis and...
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Double base mismatches mediated catalytic hairpin assembly for enzyme-free single-base mutation detection: integrating signal recognition and amplification in one
Single nucleotide polymorphism (SNP) biosensors are emerging rapidly for their promising applications in human disease prevention diagnosis,...
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MNAzyme catalyzed signal amplification-mediated lateral flow biosensor for portable and sensitive detection of mycotoxin in food samples
Here, an enzyme-free lateral flow aptasensor was designed by target-induced strand-displacement effect and followed by the activation of...
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Low bias multiple displacement amplification with confinement effect based on agarose gel
Multiple displacement amplification (MDA) is a popular single-cell whole-genome amplification (WGA) technique that can greatly improve the...
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A lateral flow assay for miRNA-21 based on CRISPR/Cas13a and MnO2 nanosheets-mediated recognition and signal amplification
The point-of-care testing (POCT) of miRNA has significant application in medical diagnosis, yet presents challenges due to their characteristics of...
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Isothermal nucleic acid amplification and its uses in modern diagnostic technologies
Nucleic acids are prominent biomarkers for diagnosing infectious pathogens using nucleic acid amplification techniques (NAATs). PCR, a gold standard...
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HpaII-assisted and linear amplification-enhanced isothermal exponential amplification fluorescent strategy for rapid and sensitive detection of DNA methyltransferase activity
The detection of methyltransferase (MTase) activity is of great significance in methylation-related disease diagnosis and drug screening. Herein, a...
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An “off-on” electrochemiluminescence biosensor coupled with strand displacement-powered 3D micromolecule walking nanomachine for ultrasensitive detection of adenosine triphosphate
A three-dimensional (3D) micromolecule walking nanomachine propelled by strand displacement was developed to establish a novel switching...
