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Fluorescent immunoassay for chloramphenicol based on the label-free polyadenine-mediated spherical nucleic acids triggered signal amplification
A fluorescent immunosorbent assay incorporating signal amplification away from the surface of spherical nucleic acid (SNA) was developed for the...
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Inhibition of Non-specific Amplification in Loop-Mediated Isothermal Amplification via Tetramethylammonium Chloride
Loop-mediated isothermal amplification (LAMP) may be used in molecular and point-of-care diagnostics for pathogen detection. The amplification occurs...
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Global signal peptide profiling reveals principles of selective Sec61 inhibition
Cotransins target the Sec61 translocon and inhibit the biogenesis of an undefined subset of secretory and membrane proteins. Remarkably, cotransin...
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PfAgo-based dual signal amplification biosensor for rapid and highly sensitive detection of alkaline phosphatase activity
A Pyrococcus furiosus Argonaute ( Pf Ago)-based biosensor is presented for alkaline phosphatase (ALP) activity detection in which the ALP-catalyzed...
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Signal peptide mimicry primes Sec61 for client-selective inhibition
Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy, but attempts to target essential protein biogenesis...
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A novel electrochemical platform for assay of alkaline phosphatase based on amifostine and ATRP signal amplification
Alkaline phosphatase (ALP), an important hydrolase involved in dephosphorylation, is a common clinical indicator of many diseases. In the present...
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Smart polymer chemosensors: signal-amplification systems with allosterism
Supramolecular chemical sensing with chemosensors has attracted considerable attention over the past two decades, and today, its technology has been...
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Colorimetric detection of thrombin based on signal amplification by transcription-reverse transcription concerted reaction using non-crosslinking aggregation of gold nanoparticles
Gold nanoparticles (AuNPs) have been used as colorimetric biosensors by utilizing the difference in color between the dispersed (red) and aggregated...
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Chemical Amplification Resists for Microlithography
This chapter describes polymers employed in formulation of chemically amplified resists for microlithography, which have become the workhorse in...
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HpaII-assisted and linear amplification-enhanced isothermal exponential amplification fluorescent strategy for rapid and sensitive detection of DNA methyltransferase activity
The detection of methyltransferase (MTase) activity is of great significance in methylation-related disease diagnosis and drug screening. Herein, a...
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Electrochemical detection of the p53 gene using exponential amplification reaction (EXPAR) and CRISPR/Cas12a reactions
An improved electrochemical sensor has been developed for sensitive detection of the p53 gene based on exponential amplification reaction (EXPAR)...
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A ratiometric fluorescent nanoprobe for signal amplification monitoring of intracellular telomerase activity
Telomerase is considered a valuable diagnostic and prognostic cancer biomarker. Accurate and reliable detection of telomerase activity is of great...
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Fast and sensitive CRISPR detection by minimized interference of target amplification
Despite the great potential of CRISPR-based detection, it has not been competitive with other market diagnostics for on-site and in-home testing....
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Recombinase Polymerase and Loop-Mediated Isothermal Amplification in the DNA Diagnostics of Infectious Diseases
AbstractRecombinase polymerase and loop-mediated isothermal amplification can be conducted in nonlaboratory conditions, making these methods...
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Enzymatic reaction modulated DNA assembly on graphitic carbon nitride nanosheets for sensitive fluorescence detection of acetylcholinesterase activity and inhibition
A novel fluorescent strategy has been developed by using an enzymatic reaction modulated DNA assembly on graphitic carbon nitride nanosheets (CNNS)...
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Simplified capture, extraction, and amplification of cellular DNA from water samples
DNA analysis in water samples is attracting attention in various fields. However, conventional methods for DNA analysis require a work-intensive and...
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Cascade amplification of tumor chemodynamic therapy and starvation with re-educated TAMs via Fe-MOF based functional nanosystem
Tumor microenvironment is characterized by the high concentration of reactive oxygen species (ROS), which is an effective key used to open the...
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A Controlled Transcription-Driven Light-Up Aptamer Amplification for Nucleoside Triphosphate Detection
In this study, we introduced a simple method for detecting nucleoside triphosphates (NTPs) using controlled transcription-driven light-up aptamer...
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Intelligent nanovesicle for remodeling tumor microenvironment and circulating tumor chemoimmunotherapy amplification
Imperceptible examination and unideal treatment effect are still intractable difficulties for the clinical treatment of pancreatic ductal...
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Mayaro virus detection by integrating sample preparation with isothermal amplification in portable devices
Mayaro virus (MAYV) is an emerging mosquito-borne alphavirus that causes clinical symptoms similar to those caused by Chikungunya virus (CHIKV),...
