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The occurrence of seven-fold helical molecular conformation in cellulose-phosphoric acid complex
Phosphoric acid is widely used for the swelling and hydrolysis of cellulose. The detailed description of molecular interactions between cellulose and...
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Strategic optimization of conditions for the solubilization of GST-tagged amphipathic helix-containing ciliary proteins overexpressed as inclusion bodies in E. coli
Expression of affinity-tagged recombinant proteins for crystallography, protein–protein interaction, antibody generation, therapeutic applications,...
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The Structural Features of MlaD Illuminate its Unique Ligand-Transporting Mechanism and Ancestry
The membrane-associated solute-binding protein (SBP) MlaD of the maintenance of lipid asymmetry (Mla) system has been reported to help the transport...
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Selection of a promiscuous minimalist cAMP phosphodiesterase from a library of de novo designed proteins
The ability of unevolved amino acid sequences to become biological catalysts was key to the emergence of life on Earth. However, billions of years of...
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Combinatorial protein dimerization enables precise multi-input synthetic computations
Bacterial transcription factors (TFs) with helix-turn-helix (HTH) DNA-binding domains have been widely explored to build orthogonal transcriptional...
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NMR structure and functional studies of the fourth FAS1 domain of human periostin
Periostin is a matricellular protein that consists of several structural and functional domains, including EMILIN-like, four internal repeat...
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Mutagenetic analysis of the biosynthetic pathway of tetramate bripiodionen bearing 3-(2H-pyran-2-ylidene)pyrrolidine-2,4-dione skeleton
BackgroundNatural tetramates are a family of hybrid polyketides bearing tetramic acid (pyrrolidine-2,4-dione) moiety exhibiting a broad range of...
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Unveiling dissociation mechanisms and binding patterns in the UHRF1-DPPA3 complex via multi-replica molecular dynamics simulations
ContextUbiquitin-like with PHD and RING finger domain containing protein 1 (UHRF1) is responsible for preserving the stability of genomic methylation...
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Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin
Indirubin is a bisindole compound for the treatment of chronic myelocytic leukemia. Here, we presented a structure-guided method to improve the...
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Identification and characterization of antimicrobial peptide (AMP) candidate from Gonggong Sea Snail (Leavistrombus turturella) extract
This study aimed to explore the potency of Gonggong sea snail’s (GSS) extract as an antimicrobial peptide (AMP) source. The results showed that the...
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Structural basis of colibactin activation by the ClbP peptidase
Colibactin, a DNA cross-linking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance...
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Supramolecular Organization of Foldable Phenylene Ethynylene Oligomers
This review summarizes the supramolecular organization of foldable phenylene ethynylene (PE) oligomers and polymers. m-Phenylene ethynylenes (mPEs)...
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Unraveling the potential of uninvestigated thermoalkaliphilic lipases by molecular docking and molecular dynamic simulation: an in silico characterization study
Thermoalkaliphilic lipase enzymes are mostly favored for use in the detergent industry. While there has been considerable research on Geobacillus ...
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Analysis and Observation of Polymer Crystal Structures at the IndividualStem Level
Several theories or schemes of polymer crystallization that differ from classical nucleationand growth processes have been put forth recently. They...
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Design of short peptides and peptide amphiphiles as collagen mimics and an investigation of their interactions with collagen using molecular dynamics simulations and docking studies
Short peptide sequences and bolaamphiphiles derived from natural proteins are gaining importance due to their ability to form unique nanoscale...
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AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus
BackgroundAdpA is a global regulator of morphological differentiation and secondary metabolism in Streptomyces, but the regulatory roles of the Streptomyces...
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Inhibitory effect of lignin on the hydrolysis of xylan by thermophilic and thermolabile GH11 xylanases
BackgroundEnzymatic hydrolysis of lignocellulosic biomass into platform sugars can be enhanced by the addition of accessory enzymes, such as...
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The folding propensity of α/sulfono-γ-AA peptidic foldamers with both left- and right-handedness
The discovery and application of new types of helical peptidic foldamers have been an attractive endeavor to enable the development of new materials,...
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RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds
RNA origami is a framework for the modular design of nanoscaffolds that can be folded from a single strand of RNA and used to organize molecular...
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Shedding light on structure, function and regulation of human sirtuins: a comprehensive review
Sirtuins play an important role in signalling pathways associated with various metabolic regulations. They possess mono-ADP-ribosyltransferase or...
