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Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study
A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized based on cyanoacrylamide derivatives containing 2,4-dichlro...
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Specific Features of Binding Bioactive Organic Molecules with the Metallic Matrix of Heteronuclear 3d-4f Structures Containing Soft and Hard Metallocenters Using the Nd(III)–Cu(II) Complex as an Example
AbstractThe polynuclear alanine hydroximate metallamacrocyclic complex Nd(C 8 H 7 NO 4 )(H 2 O)[15-MC Cu(II)Alaha -5](CH 3 COO) with the axial...
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Crystal Structure of Halogenated N-Methylquinoline-2-Ones: Preparation and Study of Intermolecular Interactions in Crystals
AbstractA series of novel N-methylquinoline-2-ones with a fluorinated benzene ring (with and without Br atoms) is prepared by the interaction of...
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Recent advances in therapeutical applications of the versatile hydroxypyridinone chelators
Hydroxypyridinones (HOPOs) are excellent class of chelators that have been gaining attention in the field of pharmaceutical drugs by their high...
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The Chemistry of 2-(1H)-Pyrazinones in Solution and on Solid Support
An overview on the microwave-enhanced synthesis and decoration of the 2(1H)-pyrazinone system is presented. Scaffold decoration using...
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Photocatalysed Synthesis and Structure Activity Evaluation of Cyclohexyloxyphenethylpyridinones as Potent HIV-1 Inhibitor
A visible light promoted, photoredox catalysed, green one-pot approach for the synthesis of cyclohexyloxyphenethylpyridinoneshas been developed. New...
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TMACH-1,2-HOPO, a versatile tripodal metal chelator: complexation, solution thermodynamics, spectroscopic and DFT studies
A new tripodal siderophore-mimic hexadentate chelator,...
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Synthesis of new potentially biologically active pyranopyridones with tryptamine fragment
New pyranopyridonotryptamines 3 were synthesized by a three-component reaction of pyridonotryptamines 1 , aromatic aldehydes 2 , and malononitrile. The...
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Chiral Ureas and Thiroureas in Asymmetric Catalysis
After an overview of chiral urea and thiourea synthetic methods, this review describes the main applications of urea and thiourea complexes in...
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Cyanomethyl pyridinium and isoquinolinium salts: a versatile chemical reagent for the synthesis of annulated heterocycles
Over the years, numerous advancements have been in synthesizing various heterocyclic compounds using pyridinium ylides. Imidazo pyridine derivatives...
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Practical N-to-C peptide synthesis with minimal protecting groups
Accessible drug modalities have continued to increase in number in recent years. Peptides play a central role as pharmaceuticals and biomaterials in...
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Current Scenario of Pyridine/Quinoline-Sulfonamide Hybrids with Anticancer Potential (A Review)
AbstractCancer, which proliferates and spreads uncontrollably due to the accumulation of genetic and epigenetic factors, is one of the most fatal...
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Role of Computational Modeling in Drug Discovery for Alzheimer’s Disease
Researchers are striving hard for the last two decades to discover new therapeutically effective molecules for the treatment of Alzheimer’s...
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Seminar “New Organic Functional Materials”
AbstractThe seminar “New Organic Functional Materials” was held from July 3 to 6, 2023, at St. Petersburg State University as part of the All-Russian...
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Cooperative triple catalysis enables regioirregular formal Mizoroki–Heck reactions
The Mizoroki–Heck reaction between alkenes and aryl halides represents one of the most important methods for C−C bond formation in synthetic...
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C-halogen…pi interactions in nucleic acids: a database study
AbstractA Protein Data Bank study was conducted to check the role of C-halogen(X)…pi interactions (X = F, Cl, Br, I) in nucleic acids. The presence...
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Current Scenario of Pleuromutilin Derivatives with Antibacterial Potential (A Review)
AbstractThe dramatic increase in antibiotic resistance and the emergence of superbugs have placed renewed emphasis on the importance of development...
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On the coordination chemistry of a bacterial siderophore cepabactin from a theoretical perspective
Iron is one of the essential metals required by almost all living organisms. However, nature has certain constraints in distributing this element...
