Search
Search Results
-
A Silver Nanoprism-Based “Off-On” Sensor for Phenytoin Determination in Exhaled Breath Condensate
The present research proposed the use of silver nanoprism in a fluorescent system for phenytoin determination in exhaled breath condensate samples....
-
Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures
Improving the efficiency of antiseizure medication entering the brain is the key to reducing its peripheral toxicity. A combination of intranasal...
-
Development of a useful single-reference HPLC method for therapeutic drug monitoring of phenytoin and carbamazepine in human plasma
A single reference high-performance liquid chromatographic (SR-HPLC) method was developed and validated for the therapeutic drug monitoring (TDM) of...
-
A novel facile approach to obtain phenytoin and thiophenytoin using new deep eutectic solvent-like mixtures of urea, thiourea, and KOH
Urea and thiourea formed relatively stable liquid deep eutectic mixtures with KOH at certain ratios. These mixtures showed high activity in the...
-
In silico investigation of potential phytoconstituents against ligand- and voltage-gated ion channels as antiepileptic agents
The most promising anticonvulsant phytocompounds were explored in this work using docking, molecular dynamic (MD) simulation, and Molecular...
-
In-situ microscale spectrophotometric determination of phenytoin by using branched gold nanoparticles
A rapid method for the sensitive detection of phenytoin (PHT) by branched gold nanoparticles (B-AuNPs) is described. These nanoparticles were...
-
Molecularly imprinted polymer-based extended-gate field-effect transistor chemosensors for selective determination of antiepileptic drug
Ultrathin molecularly imprinted polymer (MIP) films were deposited on the surfaces of ZnO nanorods (ZNRs) and nanosheets (ZNSs) by...
-
Fabrication and Characterization of Biodegradable pH-Responsive Halloysite Poly(lactic-co-glycolic acid) Micro-sphere for Controlled Released of Phenytoin Sodium
In this paper, new porous pH-responsive microspheres based on functionalized halloysite nanotubes (HNTs) with poly-lactic- co -glycolic acid (PLGA) are...
-
Two- and three-directional synthesis by 3–7CRs of novel (imidazolidine/thiazolidine)-2,4-diones: preparation, antibacterial, anticonvulsant, and molecular docking investigation
A variety of new compounds containing two or three biologically active imidazolidine-2,4-dione and thiazolidine-2,4-dione (TZD) cores through two-...
-
Bioanalytical technologies using temperature-responsive polymers
In recent decades, various bioanalytical technologies have been investigated for appropriate medical treatment and effective therapy....
-
Medication Safety in Older People
This chapter considers implications for medication safety due to pharmacokinetic and pharmacodynamic changes affecting the handling of medicines in...
-
Synthesis, Characterization, and Biological Evaluation of 2-(p-Nitrophenyl)quinazolin-4(3H)-one Derivatives
AbstractA series of novel 2-(4-nitrophenyl)-3-(R-benzothiazol-2-yl)quinazolin-4(3 H )-ones 4a–4g (R = Alk, AlkO, Hal, NO 2 ) were synthesized from the...
-
Speedy Gonzales analysis method in one drop of beverage, for crimes committed with drugs from three different groups
Sertraline, zolpidem and fentanyl, are drugs with potential to be used in cases of rape, property theft and organ theft. In this study, a 15 min...
-
Development and validation of a high-performance thin-layer chromatography densitometric method for the simultaneous determination of novel 1-acridinyl-1,2,3-triazole derivatives
High-performance thin-layer chromatographic (HPTLC) method provides a simple, sensitive, and accurate analytical method for the simultaneous...
-
Disease Influence on BBB Transport in Neurodegeneration
For the pharmacotherapy of neurodegenerative diseases, drugs must pass the blood–brain barrier (BBB). The BBB seems to play an important role in...
-
Development of Efficient Strategies for Physical Stimuli-Responsive Programmable Nanotherapeutics
Stimuli-responsive nanomaterials have received lots of attention in biomedical research due to their responsiveness to different therapies under...
-
Brahmi
Bacopa monnieri (common name: Brahmi), is an herb containing a plethora of phytochemicals of extreme medicinal importance. It belongs to the family...
-
Imidazole, Hydantoins, Thiazole, and Oxazole: A Journey on Synthetic and Biological Relevance
Imidazole ring is undoubtedly one of the most prominent building blocks for different compounds, either natural or synthetic. The strategies used for...
-
Photostability evaluation of manidipine tablets and structural determination of its photoproducts
Manidipine (MP) is a dihydropyridine drug, which is treated for the reduction of high blood pressure. The aim of this study is to clarify the...
-
Quantitative LC-MS/MS Method for the Simultaneous Measurement of Six Antiepileptics and Pentobarbital in Human Serum
Antiepileptic drugs (AEDs) are a chemically diverse group of medications that are used to control seizures and different clinical forms of epilepsy....