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A novel facile approach to obtain phenytoin and thiophenytoin using new deep eutectic solvent-like mixtures of urea, thiourea, and KOH

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Chemistry of Heterocyclic Compounds Aims and scope

Urea and thiourea formed relatively stable liquid deep eutectic mixtures with KOH at certain ratios. These mixtures showed high activity in the reaction with benzils, quickly forming hydantoins and thiohydantoins in high yields.

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Authors and Affiliations

  1. Tomsk Polytechnic University, Kizhner Research Center, 43a Lenina Ave., Tomsk, 634050, Russia

    Elena V. Khovrenko, Vadim Yu. Baula, Viktoria V. Shtrykova, Vera Yu. Kuksenok & Victor D. Filimonov

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  1. Elena V. Khovrenko
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  2. Vadim Yu. Baula
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  3. Viktoria V. Shtrykova
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  4. Vera Yu. Kuksenok
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  5. Victor D. Filimonov
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Corresponding author

Correspondence to Victor D. Filimonov.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2024, 60(1/2), 103–106

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Khovrenko, E.V., Baula, V.Y., Shtrykova, V.V. et al. A novel facile approach to obtain phenytoin and thiophenytoin using new deep eutectic solvent-like mixtures of urea, thiourea, and KOH. Chem Heterocycl Comp 60, 103–106 (2024). https://doi.org/10.1007/s10593-024-03300-8

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  • DOI: https://doi.org/10.1007/s10593-024-03300-8

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