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Overcoming multidrug-resistant lung cancer by mitochondrial-associated ATP inhibition using nanodrugs
Despite the development of therapeutic modalities to treat cancer, multidrug resistance (MDR) and incomplete destruction of deeply embedded lung...
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Isolation and molecular characterization of multidrug‑resistant Escherichia coli from chicken meat
Antibiotics in animal farms play a significant role in the proliferation and spread of antibiotic-resistant genes (ARGs) and antibiotic-resistant...
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Gold Nanoparticles: A Lethal Nanoweapon Against Multidrug-Resistant Bacteria
Multidrug-resistant (MDR) bacteria, also called superbugs, pose serious threat to the human health and existence because of their ability to develop...
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Nanoformulations Against Multidrug-Resistant Members of ESKAPE Pathogens
The rise and spread of antimicrobial resistance (AMR) and drug-resistant nosocomial infections have become a significant global threat for human...
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MMP-2 and upconverted UV dual-mediated drug sequential delivery and on-site immobilization for enhanced multidrug-resistant cancer therapy
Controlled drug delivery holds great potential for effective tumor treatment owing to the merits of overcoming drug resistance and improving...
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Nanotheranostic Trojan Horse for visualization and photo-immunotherapy of multidrug-resistant bacterial infection
Effective diagnosis and therapy for bacterial infections, especially those caused by multidrug-resistant (MDR) species, greatly challenge current...
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Dual-targeting tigecycline nanoparticles for treating intracranial infections caused by multidrug-resistant Acinetobacter baumannii
Multidrug-resistant (MDR) Acinetobacter baumannii ( A. baumannii ) is a formidable pathogen responsible for severe intracranial infections...
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Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer
Cancer often develops multidrug resistance (MDR) when cancer cells become resistant to numerous structurally and functionally different...
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Unraveling the draft genome and phylogenomic analysis of a multidrug-resistant Planococcus sp. NCCP-2050T: a promising novel bacteria from Pakistan
Planococcus is a genus of Gram-positive bacteria known for potential industrial and agricultural applications. Here, we report the first draft genome...
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The Antibacterial and Antibiofilm Activities of the Endophytic Bacteria Associated with Archidendron pauciflorum against Multidrug-Resistant Strains
Endophytes associated with medicinal plants are a potential source of valuable natural products. This study aimed to evaluate the antibacterial and...
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In silico identification of phytochemical inhibitors for multidrug-resistant tuberculosis based on novel pharmacophore generation and molecular dynamics simulation studies
BackgroundMultidrug-resistant tuberculosis (particularly resistant to pyrazinoic acid) is a life-threatening chronic pulmonary disease. Running a...
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Isolation and Characterization of Antimicrobial Peptides Isolated from Brevibacillus halotolerans 7WMA2 for the Activity Against Multidrug-Resistant Pathogens
Multidrug resistance to pathogens has posed a severe threat to public health. The threat could be addressed by antimicrobial peptides (AMPs) with...
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Short antimicrobial peptidomimetic SAMP-5 effective against multidrug-resistant gram-negative bacteria
SAMP-5 is a short histidine-derived antimicrobial peptidomimetic with pendant dialkylated tail. In this study, we evaluated the potential of SAMP-5...
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Chitosan/Pectin Nanoparticles Encapsulated with Echinacea pallida: a Focus on Antibacterial and Antibiofilm Activity Against Multidrug-Resistant Staphylococcus aureus
In recent years, the alarming spread of antibiotic resistance has posed a grave global threat to public health, resulting in millions of fatalities...
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In vitro and in vivo photodynamic efficacies of novel and conventional phenothiazinium photosensitizers against multidrug-resistant Candida auris
The fast-emerging and multidrug-resistant Candida auris is the first fungal pathogen to be considered a threat to global public health. Thus, there...
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A Novel Polythiophene-Conjugated Polymer Photocatalyst Under Visible Light for Killing Multidrug-Resistant Bacteria
The photocatalytic antibacterial method is one of the most effective and “green” methods for treating multidrug resistant (MDR) bacteria-caused...
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Tannin coordinated nanozyme composite-based hybrid hydrogel eye drops for prophylactic treatment of multidrug-resistant Pseudomonas aeruginosa keratitis
Pseudomonas aeruginosa infection is a severe acute suppurative ulcer that engulfs virtually the entire tissue in a short period and leads to...
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Silver nanoparticle synthesis and their potency against multidrug-resistant bacteria: a green approach from tissue-cultured Coleus forskohlii
Drug resistance is a major concern nowadays, and finding alternatives of the well-known antibiotic is necessary. Green nanoparticles are emerging as...
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Perturbing tumor cell metabolism with a Ru(II) photo-redox catalyst to reverse the multidrug resistance of lung cancer
The novel concept of enzyme photocatalysis has recently attracted much attention in develo** anticancer therapy. However, the relationship between...
