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Crithmum maritimum Extract Restores Lipid Homeostasis and Metabolic Profile of Liver Cancer Cells to a Normal Phenotype
Hepatocellular carcinoma (HCC) is an alarming epidemiological clinical problem worldwide. Pharmacological approaches currently available do not...
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Metabolic Engineering
Metabolic engineering is a powerful methodology aimed at intelligently designing new biological pathways, systems, and ultimately phenotypes...
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Metabolic Phenotype Intricacies on Altered Glucose Metabolism of Breast Cancer Cells upon Glut-1 Inhibition and Mimic Hypoxia In Vitro
Breast cancer is the frequently diagnosed cancer and the leading cancer death among women. The growing tumour of the breast is composed of both...
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LC–qTOF-MS analysis of fish immune organs reveals the distribution of amino acids in response to metabolic adaptation of the survival phenotype in grouper against Vibrio infection
Epinephelus fuscoguttatus is economically crucial to various Southeast Asia countries where they are reared in fish farms to meet the demand for...
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Applying Metabolic Profiling Techniques for Stimulus-Response Experiments: Chances and Pitfalls
So far it is mainly transcriptome and proteome analysis that has been applied to elucidate the correlation between genotype and phenotype although...
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Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions
BackgroundGenome-scale metabolic model (GSMM) is a powerful tool for the study of cellular metabolic characteristics. With the development of...
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The Western Diet Puzzle: Connecting Metabolic Dysfunction to Cognitive and Neurological Consequences
There has been a significant rise in the consumption of Western diet (WD), which are diets composed of high levels of processed sugar and saturated...
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Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID
SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic capacity; therefore, it is critical for the viral pathogen to hijack host...
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Metabolic engineering of Escherichia coli for the production of 5-aminolevulinic acid based on combined metabolic pathway modification and reporter-guided mutant selection (RGMS)
Background5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields such as medicine, nutrition...
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Plant-based diet adherence is associated with metabolic health status in adults living with and without obesity
PurposeMetabolic health phenotypes exist across the body mass index spectrum. Diet may be an important modifiable risk factor, yet limited research...
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Metabolic modeling of microorganisms involved in anaerobic digestion
Anaerobic digestion (AD) is a biological process where bacteria digest various types of organic matter under anaerobic conditions. AD has been...
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Nanozyme as a rising star for metabolic disease management
Nanozyme, characterized by outstanding and inherent enzyme-mimicking properties, have emerged as highly promising alternatives to natural enzymes...
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Reconstruction of genome-scale metabolic models of non-conventional yeasts: current state, challenges, and perspectives
Non-conventional yeasts are promising cell factories to produce lipids and oleochemicals, metabolites of industrial interest ( e.g ., organics acids,...
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Metabolic Engineering of Lipid Biosynthesis Pathway to Enhance the Oil Content in Microalgae
Today, a large range of software programmes are used in the field of metabolic engineering. Such applications were shaped to provide support for a...
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Backcrossing Modulates the Metabolic Profiles of Anthocyanin-Pigmented ‘Vitamaize’ Lines Derived from Elite Maize Lines
Vitamaize lines (VMLs) were created by backcrossing the pigmented aleurone trait into Centro Internacional de Mejoramiento de Maíz y Trigo (CIMMYT)...
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Regulatory Roles of MicroRNAs in the Pathogenesis of Metabolic Syndrome
Metabolic syndrome refers to a group of several disease conditions together with high glucose triglyceride levels, high blood pressure, lower...
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Quantitative Methods for Metabolite Analysis in Metabolic Engineering
We present a brief overview of metabolic engineering, depicting the necessity of exploiting microorganisms for obtaining desired metabolites and the...
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Overexpression of Long Non-coding RNA uc.246 Facilitates Angiogenesis, Migration, and EMT Phenotype of Human Breast Cancer Cells
Breast cancer is the most malignant subtype of gynecological tumors and with aggressive biological behavior and poor outcome. Ultra-conserved...
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Metabolic Fate of Food and Its Bioavailability
Food bioactive components have garnered greater attention due to their effect in the prevention and therapeutic value against diseases. In this...
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Metabolic recycling of storage lipids promotes squalene biosynthesis in yeast
BackgroundMetabolic rewiring in microbes is an economical and sustainable strategy for synthesizing valuable natural terpenes. Terpenes are the...
