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Assessment of iridoid profiles in the growth period of aerial parts of Pseudolysimachion rotundum var. subintegrum and their antioxidant and MUC5AC inhibitory potential
YPL-001 is a drug substance of Pseudolysimachion rotundum var. subintegrum and has been reported to be a potent COPD inhibitor. For the first time,...
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Biological Influence of Pulmonary Disease Conditions Induced by Particulate Matter on Microfluidic Lung Chips
Particulate matter (PM10)-induced respiratory illnesses are difficult to investigate in trans-well culture systems. Microphysiological systems offer...
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Immunological Roles of CCL18 in Pan‑Cancer and Its Potential Value in Endometrial Cancer
Endometrial cancer (EC) is one of the most prevalent malignancies in the female reproductive system. However, the potential functions and mechanisms...
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Low dose administration of mature silkworm powder induces gastric mucosal defense factors in ethanol-induced gastric injury rat model
Gastric mucosa is important to protect the gastric damage against external factors. We previously reported the gastro-protective effects of steamed...
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Targeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma
Asthma is a chronic inflammatory disease triggered by allergic reactions in the bronchia. These reactions lead to swelling of mucous membranes,...
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Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity
Mucins are large gel-forming polymers inside the mucus barrier that inhibit the yeast-to-hyphal transition of Candida albicans , a key virulence trait...
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Jabara (Citrus jabara)
The consumption of fruit and fruit extracts with diet is one of the traditional and existing habits which helps supplement the critical nutrition to...
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Functional and biological activities of Edible Bird’s Nest (EBN) protein by proteomic and bioinformatic analyses
Edible Bird's Nest (EBN) is a traditional food in Southeast Asia that has been consumed for centuries. In addition to its high protein content,...
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Role of Probiotics in Gut Micro-flora
Human gastro-intestinal tract is inhabited by the most diverse cluster of microorganisms known as gut micro-flora and actively partake in numerous...
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Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production
Colonic mucus layers protect intestinal tissues against intestinal bacteria. We investigated the effects of dietary fiber and its metabolites on...
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A family of di-glutamate mucin-degrading enzymes that bridges glycan hydrolases and peptidases
Microbes utilize polysaccharides to protect their surfaces and build biofilms, whereas metazoans employ large mucins densely decorated with O -glycans...
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Licorice
More than 30 species of the Glycyrrhiza genus can be found all over the world. It was the herb that was most frequently advised in Ancient Egypt,...
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Scutellarin: Bioactivities, Pharmacology, and Development as Promising Therapeutic Agents and Nutraceuticals
Scutellarin is a polyphenolic flavone with a characteristic C7-glucuronide substituent. It is widely distributed in nature, particularly in the mint...
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Afzelin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology
Afzelin, also known as kaempferol 3-O-rhamnoside, is a flavonol glycoside natural product derived from kaempferol, found in various plant species...
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Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems
Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient...
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Novel inhalation therapy in pulmonary fibrosis: principles, applications and prospects
Pulmonary fibrosis (PF) threatens millions of people worldwide with its irreversible progression. Although the underlying pathogenesis of PF is not...
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Recent Trends in Drug Delivery and Emerging Biomedical Applications of Gelatin for Ophthalmic Indications
Gelatin serves as a versatile carrier system for delivering therapeutically active agents to the ocular surface owing to its inherent attributes like...
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Development of a Human Respiratory Mucosa-on-a-chip using Decellularized Extracellular Matrix
The airway mucosa is the first point of exposure to all inhalant materials. It is possible to produce microenvironments functionally similar to...
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Ginkgetin: Advances on Resources, Bioactivity, and Pharmacology
Ginkgetin is the first known biflavonoid, isolated from the leaves of Ginkgo biloba L. after which it was named. It is a derivative of amentoflavone...