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Lysine Acetylation Stoichiometry Analysis at the Proteome Level
Lysine acetylation is a widespread posttranslational modification (PTM) in all kingdoms of live. A large number of proteins involved in most of...
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Survey of Acetylation for Thermoanaerobacter tengcongensis
Non-histone protein acetylation is involved in key cellular processes both in eukaryotes and prokaryotes. Acetylation in bacteria is used to modify...
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Genetically Encoded Noncanonical Amino Acids in Proteins to Investigate Lysine Benzoylation
Posttranslational modifications (PTMs) of lysine residues are major regulators of gene expression, protein–protein interactions, and protein...
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Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1
Biochemical crosstalk between two or more histone modifications is often observed in epigenetic enzyme regulation, but its functional significance in...
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The Global Acetylation Profiling Pipeline for Quick Assessment of Protein N-Acetyltransferase Specificity In Cellulo
Global acetylation profiling (GAP) consists of heterologous expression of a given N-acetyltransferase (NAT) in Escherichia coli to assess its...
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The Acetylation Modification of SP1 Regulates the Protein Stability in Silkworm
Acetylation is a highly conservative and reversible post-translational modification. Acetylation modification can regulate gene expression by...
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Reversible lysine-targeted probes reveal residence time-based kinase selectivity
The expansion of the target landscape of covalent inhibitors requires the engagement of nucleophiles beyond cysteine. Although the conserved...
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Repurposing a plant peptide cyclase for targeted lysine acylation
Transpeptidases are powerful tools for protein engineering but are largely restricted to acting at protein backbone termini. Alternative enzymatic...
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TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription
Protein lysine 2-hydroxyisobutyrylation (Khib) has recently been shown to play a critical role in the regulation of cellular processes. However, the...
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Protein acetylation regulates xylose metabolism during adaptation of Saccharomyces cerevisiae
BackgroundAs the second most abundant polysaccharide in nature, hemicellulose can be degraded to xylose as the feedstock for bioconversion to fuels...
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Comprehensive profiling and kinetic studies of glycated lysine residues in human serum albumin
Lysine residues of proteins slowly react with glucose forming Amadori products. In hyperglycemic conditions, such as diabetes mellitus, this...
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Identification of Potential Hits against Fungal Lysine Deacetylase Rpd3 via Molecular Docking, Molecular Dynamics Simulation, DFT, In-Silico ADMET and Drug-Likeness Assessment
Fungal histone deacetylases (HDACs) are enzymes known for their crucial role in gene expression regulation through histone deacetylation, leading to...
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Antemortem Stress Regulates Postmortem Glycolysis in Muscle by Deacetylation of Pyruvate Kinase M1 at K141
It is well known that preslaughter (antemortem) stress such as rough handling, transportation, a negative environment, physical discomfort, lack of...
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Computational investigation on the effect of the lysine 2-hydroxyisobutyrylation on argininosuccinate synthetase 1 conformational dynamics in Botrytis cinerea
Lysine 2-hydroxyisobutyrylation (Khib) is a newly discovered post-translational modification in recent years, which has been identified in several...
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A proteome-wide atlas of lysine-reactive chemistry
Recent advances in chemical proteomics have begun to characterize the reactivity and ligandability of lysines on a global scale. Yet, only a limited...
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Lysine reactivity profiling reveals molecular insights into human serum albumin–small-molecule drug interactions
Human serum albumin (HSA) is one of the most important serum carrier proteins that deliver small-molecule drugs to their specific targets. Clarifying...
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A dual-function chemical probe for detecting erasers of lysine lipoylation
Lysine lipoylation plays vital roles in cell metabolism and redox processes. For example, removal of lipoylation will decrease pyruvate dehydrogenase...
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Utilization in situ of biodegradable films produced with chitosan, and functionalized with ε-poly-l-lysine: an effective approach for super antibacterial application
In this study, the chitosan (1% w/v) was hydrated in an aqueous solution of glacial acetic acid (1% w/v) by using a magnetic stirrer and mixed with...
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Sirtuin1 (SIRT1) is involved in the anticancer effect of black raspberry anthocyanins in colorectal cancer
PurposeAbnormal acetylation modification is a common epigenetic change in tumorigenesis and is closely related to the progression of colorectal...
