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Fragment-based drug design of novel inhibitors targeting lipoprotein (a) kringle domain KIV-10-mediated cardiovascular disease
Cardiovascular diseases (CVDs) are the leading cause of death globally, attributed to a complex etiology involving metabolic, genetic, and...
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Facile preparation of amino acid-assisted Fe3O4 nanoparticles for low-density lipoprotein cholesterol removal
Cholesterol is a lipid molecule in protein and cell membrane and precursor of bile acids, steroids hormones and vitamin D. Higher level of...
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High-density lipoprotein mimetic nano-therapeutics targeting monocytes and macrophages for improved cardiovascular care: a comprehensive review
The prevalence of cardiovascular diseases continues to be a challenge for global health, necessitating innovative solutions. The potential of...
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Bosutinib high density lipoprotein nanoformulation has potent tumour radiosensitisation effects
Disruption of the cell cycle is among the most effective approach to increase tumour cells’ radio-sensitivity. However, the presence of dose-limiting...
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Associations between healthy food groups and platelet-activating factor, lipoprotein-associated phospholipase A2 and C-reactive protein: a cross-sectional study
PurposeTo investigate the association between pro-inflammatory markers platelet-activating factor (PAF), lipoprotein-associated phospholipase A 2 ...
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Long-term fasting improves lipoprotein-associated atherogenic risk in humans
PurposeDyslipidemia is a major health concern associated with an increased risk of cardiovascular mortality. Long-term fasting (LF) has been shown to...
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Disorder is a critical component of lipoprotein sorting in Gram-negative bacteria
Gram-negative bacteria express structurally diverse lipoproteins in their cell envelope. Here, we find that approximately half of lipoproteins...
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Circ-C16orf62 Regulates Oxidized low-density Lipoprotein-induced Apoptosis, Inflammation, Oxidative Stress and Cholesterol Accumulation of Macrophages via Mediating RAB22A Expression by Targeting miR-377
Atherosclerosis (AS) is one of the most common and important vascular diseases. It is believed that the abnormal expression of circular RNAs...
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Nitrogen-doped carbon dots/Ni-MnFe-layered double hydroxides (N-CDs/Ni-MnFe-LDHs) hybrid nanomaterials as immunoassay label for low-density lipoprotein detection
Nitrogen-doped carbon dots/Ni-MnFe-layered double hydroxides (N-CDs/Ni-MnFe-LDHs) are demonstrated as superior peroxidase mimic antibody labels...
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Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein
BackgroundCancer cell-derived extracellular vesicles (EVs) have previously been shown to contribute to pre-metastatic niche formation. Specifically,...
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Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase
Cytosolic estrogen sulfotransferase (SULT1E) mainly catalyzes the sulfate conjugation of estrogens, which decrease atherosclerosis progression....
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Dynamic AFM detection of the oxidation-induced changes in size, stiffness, and stickiness of low-density lipoprotein
BackgroundLow-density lipoprotein (LDL) is an important plasma lipoprotein transporting lipids to peripheral tissues/cells. The oxidation of LDL...
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Structural insight into the formation of lipoprotein-β-barrel complexes
The β-barrel assembly machinery (BAM) inserts outer membrane β-barrel proteins (OMPs) in the outer membrane of Gram-negative bacteria. In...
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Amelioration of C-Reactive Protein and Lectin Like Oxidized Low Density Lipoprotein Receptor Complex Induced Endothelial Dysfunction by Oligomeric Proanthocyanidins
C-reactive protein (CRP) is a well-established biochemical marker for atherosclerosis. Modification of LDL inside the artery wall favors the...
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Mechanism of the Regulation of Plasma Cholesterol Levels by PI(4,5)P2
Elevated low-density lipoprotein (LDL) cholesterol (LDLc) is one of the most well-established risk factors for cardiovascular disease, while high...
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Royal Jelly Proteins Inhibit Macrophage Proliferation: Interactions with Native- and Oxidized-Low Density Lipoprotein
Macrophage proliferation is known to correlate with macrophage accumulation in atherosclerotic plaque, and therefore its inhibition and secondary...
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Ti4+ functionalized β-cyclodextrin covalent organic framework as a new immobilized metal ion affinity chromatography platform for selective capture of phosphorylated peptides and exosomes
A Ti 4+ functionalized β-cyclodextrin covalent organic framework nanoparticle (named as β-CD-COF@Ti 4+ ) was synthesized using a one-pot method...
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LP30K protein manifested in hemocytes of Bombyx mori larva on Nosema bombycis infection and showed functional evolution based on glucose- binding domain
Infection by microsporidian Nosema bombycis induced appearance of exclusive protein conjugate of 190 kDa in hemocytes of silkworm Bombyx mori L...
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Formula optimization and in vitro lipid reducing activity evaluation of nutritious rice bran meal replacement powder
Based on the rice bran instant powder obtained by enzymolysis and spray drying of rice bran in the earlier stage, this study investigated the effects...
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Effects of Nutrients on the Control of Blood Lipids
Lipids and lipoproteins play a central role in the development of atherosclerotic cardiovascular disease (ASCVD). Dietary fatty acids and refined and...