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Glycoprobe for selective embedding in membrane rafts
Synthetic analogs of glycolipids are widely used for modification of the cell membrane with glycans. Constructs capable of selective (or even...
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Biocompatible and optically stable hydrophobic fluorescent carbon dots for isolation and imaging of lipid rafts in model membrane
Lateral heterogeneity in cell membranes features a variety of compositions that influence their inherent properties. One such biophysical variation...
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Lipid Profile Features of Detergent-Resistant Membranes of Mitochondria and Chloroplasts from Euhalophyte Halocnemum strobilaceum
The lipid composition of detergent-resistant membranes (rafts) of mitochondria and chloroplasts from annual runners of the wild halophyte Halocnemum...
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A two-photon fluorescent lipid raft probe derived from dicyanostilbene and similar to cholesterol’s structure
Lipid raft is a microdomain being rich in cholesterol and sphingolipid and closely related to neurodegenerative diseases such as Alzheimer’s disease...
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Photosensitized Lipid Oxidation: Mechanisms and Consequences to Health Sciences
Photoinduced lipid oxidation starts with light absorption by photosensitizers, forming excited states that oxidize lipids by two different...
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Directly imaging emergence of phase separation in peroxidized lipid membranes
Lipid peroxidation is a process which is key in cell signaling and disease, it is exploited in cancer therapy in the form of photodynamic therapy....
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Roles of Cholesterol and PtdIns(4,5)P2 in the Regulation of STIM1–Orai1 Channel Function
Calcium is one of the most prominent second messengers. It is involved in a wide range of functions at the single-cell level but also in modulating...
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Analysis of Cholesterol from the Liver Using Gas Chromatography–Mass Spectrometry
Cholesterol is an essential lipid molecule for several biological functions including the proper functioning of cell membranes, lipoproteins, and...
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Region-specific mouse brain ganglioside distribution revealed by an improved isobaric aminoxyTMT labeling strategy with automated data processing
Gangliosides are specialized glycosphingolipids most abundant in the central nervous system. Their complex amphiphilic structure is essential to the...
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Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection
Cellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point...
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Synthesis of lipid membranes for artificial cells
A major goal of synthetic biology is to understand the transition between non-living matter and life. The bottom-up development of an artificial cell...
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Lipid composition of the cancer cell membrane
Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the...
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Biophysics of Membrane Stiffening by Cholesterol and Phosphatidylinositol 4,5-bisphosphate (PIP2)
Cell membranes regulate a wide range of phenomena that are implicated in key cellular functions. Cholesterol, a critical component of eukaryotic cell...
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Structural and functional consequences of reversible lipid asymmetry in living membranes
Maintenance of lipid asymmetry across the two leaflets of the plasma membrane (PM) bilayer is a ubiquitous feature of eukaryotic cells. Loss of this...
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Role of Lysosomal Cholesterol in Regulating PI(4,5)P2-Dependent Ion Channel Function
Lysosomes are central regulators of cellular growth and signaling. Once considered the acidic garbage can of the cell, their ever-expanding...
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Phosphatidylinositol 4,5-Bisphosphate and Cholesterol Regulators of the Calcium-Activated Chloride Channels TMEM16A and TMEM16B
Chloride fluxes through homo-dimeric calcium-activated channels TMEM16A and TMEM16B are critical to blood pressure, gastrointestinal motility,...
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Cholesterol and PIP2 Modulation of BKCa Channels
Ca2+/voltage-gated, large conductance K+ channels (BKCa) are formed by homotetrameric association of α (slo1) subunits. Their activity, however, is...
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Ca2+ and Annexins – Emerging Players for Sensing and Transferring Cholesterol and Phosphoinositides via Membrane Contact Sites
Maintaining lipid composition diversity in membranes from different organelles is critical for numerous cellular processes. However, many lipids are...
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Myconoside interacts with the plasma membranes and the actin cytoskeleton and provokes cytotoxicity in human lung adenocarcinoma A549 cells
Studies have been carried out on the effects of the phenyl glycoside myconoside, extracted from the relict, Balkan endemic resurrection plant Haberlea...
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Hybrid liposomes of DPPC/cholesterol/octyl-β-D-glucopyranoside with/without ibuprofen: thermal and morphological study
Investigation of new materials for biomedical applications has represented a relevant subject in the latest decade, enhancing versatile properties of...
