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Calcium signaling positively regulates cellulase translation and secretion in a Clr-2-overexpressing, catabolically derepressed strain of Penicillium funiculosum
BackgroundLow-cost cellulase production is vital to sustainable second-generation biorefineries. The catabolically derepressed strain of Penicillium...
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Cellular ATP redistribution achieved by deleting Tgparp improves lignocellulose utilization of Trichoderma under heat stress
BackgroundThermotolerance is widely acknowledged as a pivotal factor for fungal survival across diverse habitats. Heat stress induces a cascade of...
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Development of the thermophilic fungus Myceliophthora thermophila into glucoamylase hyperproduction system via the metabolic engineering using improved AsCas12a variants
BackgroundGlucoamylase is an important enzyme for starch saccharification in the food and biofuel industries and mainly produced from mesophilic...
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An efficient CRISPR/Cas9 genome editing system based on a multiple sgRNA processing platform in Trichoderma reesei for strain improvement and enzyme production
BackgroundThe CRISPR/Cas9 technology is being employed as a convenient tool for genetic engineering of the industrially important filamentous fungus T...
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Comparative transcriptome analysis of Trichoderma reesei reveals different gene regulatory networks induced by synthetic mixtures of glucose and β-disaccharide
The mixture of glucose and β-disaccharide (MGD) synthesized by transglycosylation of glucose as a low-cost soluble carbon source can efficiently...
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Exploring the multi-level regulation of lignocellulases in the filamentous fungus Trichoderma guizhouense NJAU4742 from an omics perspective
BackgroundFilamentous fungi are highly efficient at deconstructing plant biomass by secreting a variety of enzymes, but the complex enzymatic...
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Expression of microbial lipase in filamentous fungus Aspergillus niger: a review
Lipase has high economic importance and is widely used in biodiesel, food, detergents, cosmetics, and pharmaceutical industries. The rapid...
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Cumulative expression of heterologous XlnR regulatory modules and AraRA731V in Penicillium oxalicum enhances saccharification efficiency of corn stover and corn fiber
Penicillium o xa licum engineered strain DB2 and its mutant strains with multiple regulatory modules were constructed. Mutant strain RE-4-2 with two...
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The Ras small GTPase RSR1 regulates cellulase production in Trichoderma reesei
BackgroundLignocellulose is the most abundant renewable resource in the world and has attracted widespread attention. It can be hydrolyzed into...
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Effect of Different Pretreatment of Birch Sawdust on the Production of Active Polysaccharides by Inonotus obliquus Under Submerged Fermentation and Its Structural Mechanism
This study examined the effects of different pretreatments of birch sawdust on the production and activity of polysaccharides by Inonotus obliquus ,...
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Upgrading of efficient and scalable CRISPR–Cas-mediated technology for genetic engineering in thermophilic fungus Myceliophthora thermophila
BackgroundThermophilic filamentous fungus Myceliophthora thermophila has great capacity for biomass degradation and is an attractive system for...
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Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective
Macroscopic fungi, mainly higher basidiomycetes and some ascomycetes, are considered medicinal mushrooms and have long been used in different areas...
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Disruption of gul-1 decreased the culture viscosity and improved protein secretion in the filamentous fungus Neurospora crassa
BackgroundThe cellulolytic fungus Neurospora crassa is considered a potential host for enzyme and bioethanol production. However, large scale...
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De novo transcriptome assembly of the bamboo snout beetle Cyrtotrachelus buqueti reveals ability to degrade lignocellulose of bamboo feedstock
BackgroundThe bamboo weevil Cyrtotrachelus buqueti , which is considered a pest species, damages bamboo shoots via its piercing–sucking mode of...
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Involvement of the adaptor protein 3 complex in lignocellulase secretion in Neurospora crassa revealed by comparative genomic screening
BackgroundLignocellulase hypersecretion has been achieved in industrial fungal workhorses such as Trichoderma reesei , but the underlying mechanism...
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Development of a genome-editing CRISPR/Cas9 system in thermophilic fungal Myceliophthora species and its application to hyper-cellulase production strain engineering
BackgroundOver the past 3 years, the CRISPR/Cas9 system has revolutionized the field of genome engineering. However, its application has not yet been...
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Transcriptomic analysis of Aspergillus niger strains reveals the mechanism underlying high citric acid productivity
BackgroundAspergillus niger is a highly important industrial microorganism because of its amazing capacity to produce citric acid (CA). To explore...
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Genome-wide analysis of the endoplasmic reticulum stress response during lignocellulase production in Neurospora crassa
BackgroundLignocellulolytic fungal cells suffer endoplasmic reticulum (ER) stress during lignocellulase synthesis; however, an understanding of this...
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Identification and characterization of the glucose dual-affinity transport system in Neurospora crassa: pleiotropic roles in nutrient transport, signaling, and carbon catabolite repression
BackgroundThe glucose dual-affinity transport system (low- and high-affinity) is a conserved strategy used by microorganisms to cope with natural...
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Construction of Aspergillus niger integrated with cellulase gene from Ampullaria gigas Spix for improved enzyme production and saccharification of alkaline-pretreated rice straw
Aspergillus niger is an important microorganism that has been used for decades to produce extracellular enzymes. In this study, a novel Aspergillus...
