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Analysis of Barbiturates in Urine by LC-MS/MS
In the method described here, an aliquot of a urine sample is analyzed to detect barbiturates through dilution and ultra-high-performance...
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High-Throughput Quantitative LC-MS/MS Analysis of Benzodiazepines in Human Urine
We hereby present a fast, high-throughput, and clinical LC-MS/MS assay for the simultaneous analysis of benzodiazepines in human urine. The assay is...
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Quantitative Assay of Fentanyl and Analogs Using LC-MS/MS
Drug overdoses and drug-involved deaths continue to increase in the United States, with most drug overdose deaths involving opioidsOpioids. Among...
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Quantitative LC-MS/MS Analysis of Amphetamines and Cocaine in Human Urine
We hereby present a fast and high-throughput LC-MS/MS assay for the simultaneous analysis of amphetamines and cocaine in human urine. The assay is...
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Assessment of Iohexol Serum Clearance by LC-MS/MS with Isotopically Labeled Internal Standard
Accurate measurement of the glomerular filtration rate (GFR) is essential for detecting renal insufficiency in living kidney donors. Iohexol is a...
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Quantitative LC-MS/MS Analysis of Opiates and Opioids in Human Urine
We hereby present a direct, clinical LC-MS/MS assay for the simultaneous analysis of opiates and opioids in human urine. The assay is used as...
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High-Throughput Quantitative LC-MS/MS Analysis of Barbiturates in Human Urine
We hereby present a fast, high-throughput, and clinical LC-MS/MS assay for the simultaneous analysis of barbiturates in human urine. It is deployed...
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Metabolomics characterization of two saffron from Iran and China using GC–MS and LC–MS methods
Saffron is a medicinally important species of the Iridaceae family. Saffron’s quality depends on the concentration of secondary metabolites. In this...
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High-Throughput Comprehensive Quantitative LC-MS/MS Analysis of Common Drugs and Metabolites (62 Compounds) in Human Urine
In recent years a multitude of LC-MS/MS assays have been widely reported in commercial and clinical literature demonstrating the simultaneous...
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Determination of Pyrrolizidine Alkaloids in Plants, Pollen, and Honey by LC-ESI-MS/MS
This chapter presents a diluted-and-shot sample preparation approach for honey and solid-liquid extraction for pollen and bee plant samples to...
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Development of a simultaneous LC–MS/MS analytical method for plasma: 16 antipsychotics approved in Japan and 4 drug metabolites
The increased risk of adverse drug reactions due to the concomitant use of antipsychotics is problematic in the treatment of schizophrenia....
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Simultaneous quantification of total and free testosterone in human serum by LC–MS/MS
Testosterone (TTe) and free testosterone (FTe) are clinically important indicators for the diagnosis of androgen disorders, so accurate quantitative...
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Simultaneous determination of 14 analgesics in postoperative analgesic solution by HPLC–DAD and LC–MS/MS
A green, efficient, sensitive and accurate detection method by HPLC–DAD and LC–MS/MS was developed and validated for the quantification of morphine,...
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Chemometric−Assisted QuEChERS Method for Multiresidue Analysis of Veterinary Drugs in Pigeon Muscle by LC-MS/MS
Pigeon is an essential poultry with tasty meat and high protein content, and its breeding and consumption of meat have been increasing annually....
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Isoniazid derivatization strategy of carboxyl-containing metabolites for LC-MS/MS-based targeted metabolomics
Metabolomics is a biochemical analysis tool for identifying metabolic phenotypes and used to reveal the pathogenic mechanisms of disease and to...
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Determination of Polypeptide Antibiotics in Milk by Simple LLE Technique and LC–MS/MS Analysis
Antibiotics are widely employed worldwide in animal production, both for promoting cattle growth and for therapeutic purposes. When these drugs are...
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LC–MS/MS analysis of desmosine and isodesmosine in skipjack tuna “Katsuo” elastin
To achieve the precise quantitation of desmosine (DES) and isodesmosine (IDS) in skipjack tuna “Katsuo” elastin, an isotope dilution liquid...
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Measurement of Serum Vitamins B2 and B6 in Patients with Hashimoto’s Thyroiditis by LC–MS/MS Method
Vitamin B2 and vitamin B6 are cofactors and coenzymes in many biochemical reactions, and their sufficient serum concentrations may be crucial for the...
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LC–MS/MS separation and quantitation of ribavirin in chicken and comparison of different mass spectrometric platforms
A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the analysis of ribavirin in chicken. Samples was extracted with...
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Quantification of Thiopurine Metabolites in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
The thiopurine drugs, azathioprine, mercaptopurine, and thioguanine, are widely used in the treatment of several malignant and nonmalignant diseases....