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Immunogenicity Monitoring Cell Chip Incorporating Finger-Actuated Microfluidic and Colorimetric Paper-Based Analytical Functions
Recently, with the development of microfluidic chips, attempts to integrate cell culture and biomedical material testing functions into a single chip...
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Photoacoustic mediated multifunctional tumor antigen trap** nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity
The hypoimmunogenicity of tumors is one of the main bottlenecks of cancer immunotherapy. Enhancing tumor immunogenicity can improve the efficacy of...
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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems
Continuous glucose monitoring (CGM) systems play an increasingly vital role in the glycemic control of patients with diabetes mellitus. However, the...
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Simplifying glycan monitoring of complex antigens such as the SARS-CoV-2 spike to accelerate vaccine development
Glycosylation is a key quality attribute that must be closely monitored for protein therapeutics. Established assays such as HILIC-Fld of released...
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Use of a Ferret Model to Test Efficacy and Immunogenicity of Live Attenuated Mycobacterium avium Subspecies paratuberculosis Vaccines
Native hosts for the bacterial agent that causes Johne’s disease are ruminants, which include cattle, sheep and goats among others. These large...
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New frontiers in salivary extracellular vesicles: transforming diagnostics, monitoring, and therapeutics in oral and systemic diseases
Salivary extracellular vesicles (EVs) have emerged as key tools for non-invasive diagnostics, playing a crucial role in the early detection and...
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Monitoring process-related impurities in biologics–host cell protein analysis
During biologics development, manufacturers must demonstrate clearance of host cell impurities and contaminants to ensure drug purity, manufacturing...
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Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers
Virus-like particles (VLPs) are virus-derived structures made up of one or more different molecules with the ability to self-assemble, mimicking the...
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Nanoparticle-based theranostics in nuclear medicine
Nuclear medicine has revolutionized medical diagnostic and therapeutic interventions by employing radiopharmaceuticals for detection and treatment....
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Biopolymers and Osmolytes — A Focus towards the Prospects of Stability and Adjuvanticity of Vaccines
‘New-Gen Vaccines’ are grabbing the attention of scientists as they are much suitable for an immune-compromised group of individuals as well as...
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Therapeutic proteins: developments, progress, challenges, and future perspectives
Proteins are considered magic molecules due to their enormous applications in the health sector. Over the past few decades, therapeutic proteins have...
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Exosomes as drug delivery systems in glioma immunotherapy
Recently, the significant benefits of cancer immunotherapy for most cancers have been demonstrated in clinical and preclinical studies. However, the...
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Multifunctional fish gelatin hydrogel inverse opal films for wound healing
BackgroundWound healing has become a worldwide healthcare issue. Attempts in the area focus on develo** patches with the capabilities of avoiding...
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Engineering magnetic nano-manipulators for boosting cancer immunotherapy
Cancer immunotherapy has shown promising therapeutic results in the clinic, albeit only in a limited number of cancer types, and its efficacy remains...
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Functional nucleic acid-based cell imaging and manipulation
Cells are the basic structural and functional units of organisms. Dynamic analysis and manipulation of specific components in living cells would...
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Current and prospective strategies for advancing the targeted delivery of CRISPR/Cas system via extracellular vesicles
Extracellular vesicles (EVs) have emerged as a promising platform for gene delivery owing to their natural properties and phenomenal functions, being...
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Advances in Therapeutic Cancer Vaccines, Their Obstacles, and Prospects Toward Tumor Immunotherapy
Over the past few decades, cancer immunotherapy has experienced a significant revolution due to the advancements in immune checkpoint inhibitors...
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Extracellular vesicles: a rising star for therapeutics and drug delivery
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the same nucleic acids, proteins, and lipids as their source...
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Tobacco-Based Vaccines, Hopes, and Concerns: A Systematic Review
Emerging infectious diseases have vigorously devastated the global economy and health sector; cost-effective plant-based vaccines (PBV) can be the...
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Engineered extracellular vesicles-like biomimetic nanoparticles as an emerging platform for targeted cancer therapy
Nanotechnology offers the possibility of revolutionizing cancer theranostics in the new era of precision oncology. Extracellular vesicles (EVs)-like...
